Oxytetracycline Hydrochloride

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MedKoo CAT#: 318450

CAS#: 2058-46-0 (HCl)

Description: Oxytetracycline Hydrochloride is the hydrochloride salt form of oxytetracycline, a tetracycline derivative produced by Streptomyces rimosus exhibiting antimicrobial activity. Oxytetracycline Hydrochloride is an antibacterial compound isolated from the elaboration products of the actinomycete, Streptomyces rimosus, when grown on a suitable medium. Oxytetracycline hydrochloride interferes with binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby preventing peptide elongation and inhibiting protein synthesis. It is often used to treat skin conditions.

Chemical Structure

Oxytetracycline Hydrochloride
CAS# 2058-46-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 318450
Name: Oxytetracycline Hydrochloride
CAS#: 2058-46-0 (HCl)
Chemical Formula: C22H25ClN2O9
Exact Mass:
Molecular Weight: 496.89
Elemental Analysis: C, 53.18; H, 5.07; Cl, 7.13; N, 5.64; O, 28.98

Price and Availability

Size Price Availability Quantity
100.0mg USD 200.0 2 Weeks
200.0mg USD 250.0 2 Weeks
500.0mg USD 300.0 2 Weeks
1.0g USD 350.0 2 Weeks
2.0g USD 400.0 2 Weeks
5.0g USD 450.0 2 Weeks
10.0g USD 500.0 2 Weeks
20.0g USD 550.0 2 Weeks
50.0g USD 650.0 2 Weeks
100.0g USD 850.0 2 Weeks
200.0g USD 1050.0 2 Weeks
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Related CAS #: 2058-46-0 (HCl)   6153-64-6 (dihydrate)  

Synonym: Oxytetracycline Hydrochloride; Oxytetracycline HCl; Biosolvomycin; Oxytetracycline.HCl; Dalinmycin; Dalimycin; Oxytetracycline, Sodium Salt; Sodium Salt Oxytetracycline; Terramycin;

IUPAC/Chemical Name: (4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride


InChi Code: InChI=1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1

SMILES Code: CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O.Cl

Appearance: Light yellow to yellow solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 496.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gao C, Liu Z, Chen J, Yan Z. A novel fluorescent assay for oxytetracycline hydrochloride based on fluorescence quenching of water-soluble CdTe nanocrystals. Luminescence. 2013 May-Jun;28(3):378-83. doi: 10.1002/bio.2393. Epub 2012 Jun 19. PubMed PMID: 22715152.

2: López-Jornet P, Camacho-Alonso F, Martinez-Canovas A, Sidrach-Cardona M. Topical 1% oxytetracycline hydrochloride versus placebo in oral mucosa biopsy. Dermatol Surg. 2012 Jul;38(7Pt 1):1054-8. doi: 10.1111/j.1524-4725.2012.02399.x. Epub 2012 Mar 27. PubMed PMID: 22455385.

3: Morales-Nin B, Grau A, Pérez-Mayol S, Pastor E, Palmer M. Oxytetracycline hydrochloride vital labelling revisited: the case of Dicentrarchus labrax and Diplodus puntazzo. J Fish Biol. 2011 Mar;78(3):762-82. doi: 10.1111/j.1095-8649.2010.02887.x. PubMed PMID: 21366571.

4: Berry SL, Read DH, Walker RL, Famula TR. Clinical, histologic, and bacteriologic findings in dairy cows with digital dermatitis (footwarts) one month after topical treatment with lincomycin hydrochloride or oxytetracycline hydrochloride. J Am Vet Med Assoc. 2010 Sep 1;237(5):555-60. doi: 10.2460/javma.237.5.555. PubMed PMID: 20807134.

5: Kim H, Lee BJ, Sah H. Reverse micelle-based microencapsulation of oxytetracycline hydrochloride into poly-d,l-lactide-co-glycolide microspheres. Drug Deliv. 2007 Feb;14(2):95-9. PubMed PMID: 17364873.

6: Osofsky A, Tell LA, Kass PH, Wetzlich SE, Nugent-Deal J, Craigmill AL. Investigation of Japanese quail (Coturnix japonica) as a pharmacokinetic model for cockatiels (Nymphicus hollandicus) and Poicephalus parrots via comparison of the pharmacokinetics of a single intravenous injection of oxytetracycline hydrochloride. J Vet Pharmacol Ther. 2005 Dec;28(6):505-13. PubMed PMID: 16343282.

7: Sun XX, Zhang X, Aboul-Enein HY. Construction and characterization of potentiometric sensor for the determination of oxytetracycline hydrochloride. Farmaco. 2004 Apr;59(4):307-14. PubMed PMID: 15081348.

8: Liebenberg W, de Villiers MM, Wurster DE, Swanepoel E, Dekker TG, Lötter AP. The effect of polymorphism on powder compaction and dissolution properties of chemically equivalent oxytetracycline hydrochloride powders. Drug Dev Ind Pharm. 1999 Sep;25(9):1027-33. PubMed PMID: 10518242.

9: Elsheikh HA, Osman Intisar AM, Eltayeb IB, Salam Abdullah A. Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus). Gen Pharmacol. 1998 Sep;31(3):455-8. PubMed PMID: 9703219.

10: Izer K, Török I, Pintér-Magyar G. Stability of oxytetracycline hydrochloride in eye-drops, prepared in pharmacies. Acta Pharm Hung. 1994 Mar;64(2):63-6. PubMed PMID: 8017210.

11: Faktor JH, Frenkel Y, Mashiach S, Serr DM. Intra-amniotic injection of oxytetracycline hydrochloride for termination of mid-trimester pregnancy. Gynecol Obstet Invest. 1988;26(3):177-80. PubMed PMID: 3240887.

12: Mesiha MS, Aboutaleb AE. The prolonged release of oxytetracycline hydrochloride from ethylcellulose microcapsules. Pharmazie. 1982 Jul;37(7):493-5. PubMed PMID: 7134255.

13: Mueller-Brennecke DL, Reed SJ, Waisner DL. Turbidimetric microbiological determination of oxytetracycline hydrochloride in finished feeds and a feed premix: collaborative study. J Assoc Off Anal Chem. 1980 Sep;63(5):1038-43. PubMed PMID: 7410294.

14: Marković D, Kezele D, Kuburović D, Zivanov-Stankić D. [The action of oxytetracycline hydrochloride under in vitro conditions]. Osterr Z Stomatol. 1978 Jun;75(6):225-8. German. PubMed PMID: 283364.

15: Marković D, Zivanov-Stakić D, Radović Z, Kezele D. [Oxytetracycline and oxytetracycline hydrochloride as components of tooth dentinal calcium]. Stomatol Glas Srb. 1977 Aug-Oct;24(4):239-43. Croatian. PubMed PMID: 288214.

16: de Jong MF, Oosterwoud RA. Treatment with oxytetracycline hydrochloride in the prevention of atrophic rhinitis in baby pigs. Tijdschr Diergeneeskd. 1977 Feb 15;102(4):266-73. Dutch. PubMed PMID: 835133.

17: Markovic D, Sćepan V. [Effects of EDTA and oxytetracycline hydrochloride and their complexes with calcium on microorganisms isolated from the root canals of diseased teeth]. Stomatol Vjesn. 1977;6(3-4):17-9. Croatian. PubMed PMID: 116396.

18: Saavedra FE, Belikov VG, Soloveĭ NV. [Spectrophotometric determination of oxytetracycline hydrochloride]. Farmatsiia. 1976 Jan-Feb;25(1):78-9. Russian. PubMed PMID: 1254013.

19: Renshaw HW, Magonigle RA, Eckblad WP, Frank FW. Immunity to bovine anaplasmosis after elimination of the carrier status with oxytetracycline hydrochloride. Proc Annu Meet U S Anim Health Assoc. 1976;(80):79-88. PubMed PMID: 1078098.

20: Lal OP, Teotia TP. Influence of nine surfactants on the activity of oxytetracycline hydrochloride against Lipaphis erysimi Kalt. J Antibiot (Tokyo). 1975 Dec;28(12):993-6. PubMed PMID: 1206011.