WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407296
CAS#: 522650-83-5
Description: SW044248 is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. The acute transcriptional response to SW044248 in sensitive HCC4017 cells correlated significantly with inhibitors of topoisomerases and SW044248 inhibited topoisomerase 1 (Top1) but not topoisomerase 2. SW044248 inhibited Top1 differently from camptothecin and camptothecin did not show the same selective toxicity as SW044248. Elimination of Top1 by siRNA partially protected cells from SW044248, although removing Top1 was itself eventually toxic.
MedKoo Cat#: 407296
Name: SW044248
CAS#: 522650-83-5
Chemical Formula: C22H23N5O2S
Exact Mass: 421.1572
Molecular Weight: 421.519
Elemental Analysis: C, 62.69; H, 5.50; N, 16.61; O, 7.59; S, 7.61
Synonym: SW044248; SW-044248; SW 044248.
IUPAC/Chemical Name: 2-((5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-methoxyphenyl)butanamide
InChi Key: PEVRGVRHMMZNGI-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H23N5O2S/c1-4-18(21(28)23-15-11-7-9-13-17(15)29-3)30-22-24-20-19(25-26-22)14-10-6-8-12-16(14)27(20)5-2/h6-13,18H,4-5H2,1-3H3,(H,23,28)
SMILES Code: CCN1C2=CC=CC=C2C3=C1N=C(N=N3)SC(C(NC4=CC=CC=C4OC)=O)CC
1: Zubovych IO, Sethi A, Kulkarni A, Tagal V, Roth MG. A Novel Inhibitor of
Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer
Cell Lines. Mol Cancer Ther. 2016 Jan;15(1):23-36. doi:
10.1158/1535-7163.MCT-15-0458. Epub 2015 Dec 14. PubMed PMID: 26668189; PubMed
Central PMCID: PMC4707128.
2: Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J,
Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei
S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis
RJ, Roth MG, Minna JD, White MA. Systematic identification of molecular
subtype-selective vulnerabilities in non-small-cell lung cancer. Cell. 2013 Oct
24;155(3):552-66. doi: 10.1016/j.cell.2013.09.041. Epub 2013 Oct 24. PubMed PMID:
24243015; PubMed Central PMCID: PMC3836195.