WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407296
Description: SW044248 is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. The acute transcriptional response to SW044248 in sensitive HCC4017 cells correlated significantly with inhibitors of topoisomerases and SW044248 inhibited topoisomerase 1 (Top1) but not topoisomerase 2. SW044248 inhibited Top1 differently from camptothecin and camptothecin did not show the same selective toxicity as SW044248. Elimination of Top1 by siRNA partially protected cells from SW044248, although removing Top1 was itself eventually toxic.
MedKoo Cat#: 407296
Chemical Formula: C22H23N5O2S
Exact Mass: 421.1572
Molecular Weight: 421.519
Elemental Analysis: C, 62.69; H, 5.50; N, 16.61; O, 7.59; S, 7.61
Synonym: SW044248; SW-044248; SW 044248.
IUPAC/Chemical Name: 2-((5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-methoxyphenyl)butanamide
InChi Key: PEVRGVRHMMZNGI-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H23N5O2S/c1-4-18(21(28)23-15-11-7-9-13-17(15)29-3)30-22-24-20-19(25-26-22)14-10-6-8-12-16(14)27(20)5-2/h6-13,18H,4-5H2,1-3H3,(H,23,28)
SMILES Code: CCN1C2=CC=CC=C2C3=C1N=C(N=N3)SC(C(NC4=CC=CC=C4OC)=O)CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 421.519 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zubovych IO, Sethi A, Kulkarni A, Tagal V, Roth MG. A Novel Inhibitor of
Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer
Cell Lines. Mol Cancer Ther. 2016 Jan;15(1):23-36. doi:
10.1158/1535-7163.MCT-15-0458. Epub 2015 Dec 14. PubMed PMID: 26668189; PubMed
Central PMCID: PMC4707128.
2: Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J,
Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei
S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis
RJ, Roth MG, Minna JD, White MA. Systematic identification of molecular
subtype-selective vulnerabilities in non-small-cell lung cancer. Cell. 2013 Oct
24;155(3):552-66. doi: 10.1016/j.cell.2013.09.041. Epub 2013 Oct 24. PubMed PMID:
24243015; PubMed Central PMCID: PMC3836195.