Maprotiline Hydrochlorine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318172

CAS#: 10347-81-6

Description: Maprotiline Hydrochloride is the hydrochloride salt form of maprotiline, a tetracyclic antidepressant closely related to the tricyclic antidepressants with adrenergic activity and sedative properties. Maprotiline hydrochloride exerts its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors.

Price and Availability


USD 150
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USD 450

Maprotiline Hydrochlorine, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 318172
Name: Maprotiline Hydrochlorine
CAS#: 10347-81-6
Chemical Formula: C20H24ClN
Exact Mass:
Molecular Weight: 313.86
Elemental Analysis: C, 76.53; H, 7.71; Cl, 11.30; N, 4.46

Related CAS #: 10347-81-6 (HCl)   10262-69-8 (free)  

Synonym: Maprotiline Hydrochlorine;Maprotiline Hcl; Psymion; Ludiomil; Maprotilline HCl; Teva Brand of Maprotiline Hydrochloride;

IUPAC/Chemical Name: 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride


InChi Code: InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H


Technical Data

White to off-white solid powder.

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Ozkul A, Oztunç A. Determination of maprotiline hydrochloride in tablets by
ion-pair extraction using bromthymol blue. Pharmazie. 2000 Apr;55(4):321-2.
PubMed PMID: 10798251.

2: Ersoy L, Alpertunga B. Spectrophotometric determination of maprotiline
hydrochloride. Analyst. 1988 Nov;113(11):1745-6. PubMed PMID: 3232826.

3: North DS, Retzinger T, Thompson JD. Seizures and delirium associated with
overdosage of maprotiline hydrochloride. Clin Pharm. 1983 Jul-Aug;2(4):370-3.
PubMed PMID: 6883966.

4: Schwartz L, Swaminathan S. Maprotiline hydrochloride and convulsions: a case
report. Am J Psychiatry. 1982 Feb;139(2):244-5. PubMed PMID: 6798885.

5: Wells BG, Gelenberg AJ. Chemistry, pharmacology, pharmacokinetics, adverse
effects, and efficacy of the antidepressant maprotiline hydrochloride.
Pharmacotherapy. 1981 Sep-Oct;1(2):121-39. PubMed PMID: 6765485.

6: Trimble M. Maprotiline hydrochloride and grand-mal seizures. Br Med J. 1978
Nov 18;2(6149):1430. PubMed PMID: 102405; PubMed Central PMCID: PMC1608645.

7: Hall MJ, Russell RI. Maprotiline hydrochloride and grand-mal seizures. Br Med
J. 1978 Sep 30;2(6142):961. PubMed PMID: 101269; PubMed Central PMCID:

8: Saiz I, González Martínez JL, Velasco-Martín A. [Effect of maprotiline
hydrochloride on oxygen and glucose consumption and oxidative phosphorylation of
rat brain in vitro]. Arch Farmacol Toxicol. 1978 Apr;4(1):37-8. Spanish. PubMed
PMID: 697400.

9: Celentano AM, González Cappa SM. [Chagas' disease and blood transfusion:
trypanocidal activity of maprotiline hydrochloride and gentian violet]. Medicina
(B Aires). 1988;48(3):265-8. Spanish. PubMed PMID: 3150028.

10: Atri PB, Julius DA. Maprotiline hydrochloride associated with a clinical
state of catatonic stupor and epileptic encephalogram. J Clin Psychopharmacol.
1984 Aug;4(4):207-9. PubMed PMID: 6470193.

11: Multicenter evaluation of maprotiline hydrochloride for treatment of
depression. Clin Ther. 1984;6(2):155-62. PubMed PMID: 6367987.

12: Treatment of depression with maprotiline hydrochloride: multicenter
evaluation of efficacy and tolerability. Clin Ther. 1983;5(4):377-84. PubMed
PMID: 6347381.

13: Marks P, Anderson J, Vincent R, Hutchinson JT, Rees HM. Epileptiform seizures
with maprotiline hydrochloride. Postgrad Med J. 1979 Oct;55(648):742. PubMed
PMID: 537962; PubMed Central PMCID: PMC2425754.

14: Burley D, Jukes A, Steen J. Maprotiline hydrochloride and grand-mal seizures.
Br Med J. 1978 Oct 28;2(6146):1230. PubMed PMID: 102397; PubMed Central PMCID:

15: Shepherd GA, Kerr F. Maprotiline hydrochloride and grand-mal seizures. Br Med
J. 1978 Jun 10;1(6126):1523. PubMed PMID: 418842; PubMed Central PMCID:

16: Gónzález de Zárate JL, Martínez-Acitores IS, Velasco-Martín A. Effect of
maprotiline hydrochloride on oxygen and glucose uptake and on oxidative
phosphorylation of rat brain in vitro. Farmaco Prat. 1978;33(4):183-6. PubMed
PMID: 729774.

17: Park J, Proudfoot AT. Acute poisoning with maprotiline hydrochloride. Br Med
J. 1977 Jun 18;1(6076):1573. PubMed PMID: 871669; PubMed Central PMCID: