WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522663
CAS#: 1402601-82-4
Description: TUG-770 is a Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes.
MedKoo Cat#: 522663
Name: TUG-770
CAS#: 1402601-82-4
Chemical Formula: C19H14FNO2
Exact Mass: 307.1009
Molecular Weight: 307.3244
Elemental Analysis: C, 74.26; H, 4.59; F, 6.18; N, 4.56; O, 10.41
Synonym: TUG-770; TUG 770; TUG770.
IUPAC/Chemical Name: 3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid
InChi Key: KIZUBVPJNPVIIN-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H14FNO2/c20-18-13-14(6-8-17(18)9-10-19(22)23)5-7-15-3-1-2-4-16(15)11-12-21/h1-4,6,8,13H,9-11H2,(H,22,23)
SMILES Code: O=C(O)CCC1=CC=C(C#CC2=CC=CC=C2CC#N)C=C1F
1: Christiansen E, Hansen SV, Urban C, Hudson BD, Wargent ET, Grundmann M,
Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G,
Cawthorne MA, Ulven T. Discovery of TUG-770: A Highly Potent Free Fatty Acid
Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. ACS Med Chem
Lett. 2013 May 9;4(5):441-445. Epub 2013 Apr 8. PubMed PMID: 23687558; PubMed
Central PMCID: PMC3654565.