TUG-424

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522661

CAS#: 1082058-99-8

Description: TUG-424 is a a potent and selective free fatty acid receptor 1 agonist. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.

Chemical Structure

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TUG-424
CAS# 1082058-99-8
Instruction

Theoretical Analysis

MedKoo Cat#: 522661
Name: TUG-424
CAS#: 1082058-99-8
Chemical Formula: C18H16O2
Exact Mass: 264.12
Molecular Weight: 264.324
Elemental Analysis: C, 81.79; H, 6.10; O, 12.11

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: TUG-424; TUG424; TUG 424.

IUPAC/Chemical Name: 3-(4-(o-tolylethynyl)phenyl)propanoic acid

InChi Key:

InChi Code:

SMILES Code: O=C(O)CCC1=CC=C(C#CC2=CC=CC=C2C)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hagesaether E, Christiansen E, Due-Hansen ME, Ulven T. Mucus can change the
permeation rank order of drug candidates. Int J Pharm. 2013 Aug
16;452(1-2):276-82. doi: 10.1016/j.ijpharm.2013.05.036. Epub 2013 May 23. PubMed
PMID: 23707884.


2: Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV,
Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA,
Kostenis E, Kassack MU, Ulven T. Discovery of a potent and selective free fatty
acid receptor 1 agonist with low lipophilicity and high oral bioavailability. J
Med Chem. 2013 Feb 14;56(3):982-92. doi: 10.1021/jm301470a. Epub 2013 Jan 22.
PubMed PMID: 23294321.


3: Christiansen E, Urban C, Merten N, Liebscher K, Karlsen KK, Hamacher A,
Spinrath A, Bond AD, Drewke C, Ullrich S, Kassack MU, Kostenis E, Ulven T.
Discovery of potent and selective agonists for the free fatty acid receptor 1
(FFA(1)/GPR40), a potential target for the treatment of type II diabetes. J Med
Chem. 2008 Nov 27;51(22):7061-4. doi: 10.1021/jm8010178. PubMed PMID: 18947221.