Oxytocin acetate
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MedKoo CAT#: 319932

CAS#: 6233-83-6 (acetate)

Description: Oxytocin is a medication and hormone. As a medication, it is used to cause contraction of the uterus, which is used to start labor, increase the speed of labor, and to stop bleeding following delivery. It is used either by injection into a muscle or into a vein. Medical uses can result in excessive contraction of the uterus that can cause distress in an unborn baby. Common side effects in the mother include nausea and a slow heart rate. Oxytocin is normally produced in the hypothalamus and stored in the posterior pituitary gland. It plays a role in social bonding, sexual reproduction in both sexes, and during and after childbirth. It is released due to stretching of the cervix and uterus during labor and with stimulation of the nipples from breastfeeding.


Price and Availability

Size Price Shipping out time Quantity
500mg USD 950 2 Weeks
1g USD 1650 2 Weeks
2g USD 2650 2 Weeks
5g USD 4250 2 Weeks
10g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-24. Prices are subject to change without notice.

Oxytocin acetate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319932
Name: Oxytocin acetate
CAS#: 6233-83-6 (acetate)
Chemical Formula: C45H70N12O14S2
Exact Mass:
Molecular Weight: 1067.245
Elemental Analysis: C, 50.64; H, 6.61; N, 15.75; O, 20.99; S, 6.01


Related CAS #: 6233-83-6 (acetate)   50-56-6 (free base)    

Synonym: Orasthin; Ossitocina; Ossitocina; Oxetakain; Oxitocina; Oxoject; Oxystin; Partocon; Pitocin; Piton S; Oxt,; Oxytocin.

IUPAC/Chemical Name: (S)-N-((S)-1-((2-amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-((S)-sec-butyl)-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide acetate

InChi Key: DSZOEVVLZMNAEH-BXUJZNQYSA-N

InChi Code: InChI=1S/C43H66N12O12S2.C2H4O2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59;1-2(3)4/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64);1H3,(H,3,4)/t22-,25-,26-,27-,28-,29-,30-,31-,35-;/m0./s1

SMILES Code: O=C([C@H]1N(C([C@@H](NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=C(O)C=C2)N3)=O)=O)=O)=O)CSSC[C@H](N)C3=O)=O)CCC1)N[C@@H](CC(C)C)C(NCC(N)=O)=O.CC(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Oxytocin is a nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on smooth muscle cells, such as causing UTERINE CONTRACTIONS and MILK EJECTION.

Oxytocin was discovered in 1952.[8] It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. The wholesale cost is between 0.10 and 0.56 USD per dose as of 2014.

Oxytocin free base:
Chemical Formula: C43H66N12O12S2
Exact Mass: 1006.4365
Molecular Weight: 1007.1930
Elemental Analysis: C, 51.28; H, 6.61; N, 16.69; O, 19.06; S, 6.37


References

1: Freeman SM, Young LJ. Comparative perspectives on oxytocin and vasopressin receptor research in rodents and primates: Translational implications. J Neuroendocrinol. 2016 Mar 4. doi: 10.1111/jne.12382. [Epub ahead of print] Review. PubMed PMID: 26940141.

2: Olszewski PK, Klockars A, Levine AS. Oxytocin: a conditional anorexigen whose effects on appetite depend on the physiological, behavioral and social contexts. J Neuroendocrinol. 2016 Feb 26. doi: 10.1111/jne.12376. [Epub ahead of print] Review. PubMed PMID: 26918919.

3: Aspé-Sánchez M, Moreno M, Rivera MI, Rossi A, Ewer J. Oxytocin and Vasopressin Receptor Gene Polymorphisms: Role in Social and Psychiatric Traits. Front Neurosci. 2016 Jan 28;9:510. doi: 10.3389/fnins.2015.00510. eCollection 2015. Review. PubMed PMID: 26858594; PubMed Central PMCID: PMC4729929.

4: Lefevre A, Sirigu A. The two fold role of oxytocin in social developmental disorders: A cause and a remedy? Neurosci Biobehav Rev. 2016 Apr;63:168-76. doi: 10.1016/j.neubiorev.2016.01.011. Epub 2016 Jan 29. Review. PubMed PMID: 26828138.

5: Romano A, Tempesta B, Micioni Di Bonaventura MV, Gaetani S. From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders. Front Neurosci. 2016 Jan 12;9:497. doi: 10.3389/fnins.2015.00497. eCollection 2015. Review. PubMed PMID: 26793046; PubMed Central PMCID: PMC4709851.

6: Massey SH, Backes KA, Schuette SA. PLASMA OXYTOCIN CONCENTRATION AND DEPRESSIVE SYMPTOMS: A REVIEW OF CURRENT EVIDENCE AND DIRECTIONS FOR FUTURE RESEARCH. Depress Anxiety. 2016 Jan 12. doi: 10.1002/da.22467. [Epub ahead of print] Review. PubMed PMID: 26756305.

7: Lee SY, Lee AR, Hwangbo R, Han J, Hong M, Bahn GH. Is Oxytocin Application for Autism Spectrum Disorder Evidence-Based? Exp Neurobiol. 2015 Dec;24(4):312-24. doi: 10.5607/en.2015.24.4.312. Epub 2015 Dec 16. Review. PubMed PMID: 26713079; PubMed Central PMCID: PMC4688331.

8: van IJzendoorn MH, Bakermans-Kranenburg MJ. The role of oxytocin in parenting and as augmentative pharmacotherapy; critical issues and bold conjectures. J Neuroendocrinol. 2015 Dec 28. doi: 10.1111/jne.12355. [Epub ahead of print] Review. PubMed PMID: 26709101.

9: Wang P, Yang HP, Tian S, Wang L, Wang SC, Zhang F, Wang YF. Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity. J Neuroimmunol. 2015 Dec 15;289:152-61. doi: 10.1016/j.jneuroim.2015.11.001. Epub 2015 Nov 3. Review. PubMed PMID: 26616885.

10: Ma Y, Shamay-Tsoory S, Han S, Zink CF. Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations. Trends Cogn Sci. 2016 Feb;20(2):133-45. doi: 10.1016/j.tics.2015.10.009. Epub 2015 Nov 23. Review. PubMed PMID: 26616296.

11: Acevedo-Rodriguez A, Mani SK, Handa RJ. Oxytocin and Estrogen Receptor β in the Brain: An Overview. Front Endocrinol (Lausanne). 2015 Oct 15;6:160. doi: 10.3389/fendo.2015.00160. eCollection 2015. Review. PubMed PMID: 26528239; PubMed Central PMCID: PMC4606117.

12: Baribeau DA, Anagnostou E. Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits. Front Neurosci. 2015 Sep 24;9:335. doi: 10.3389/fnins.2015.00335. eCollection 2015. Review. PubMed PMID: 26441508; PubMed Central PMCID: PMC4585313.

13: Yamasue H. Promising evidence and remaining issues regarding the clinical application of oxytocin in autism spectrum disorders. Psychiatry Clin Neurosci. 2016 Feb;70(2):89-99. doi: 10.1111/pcn.12364. Epub 2015 Oct 16. Review. PubMed PMID: 26394796.

14: Feldman R, Monakhov M, Pratt M, Ebstein RP. Oxytocin Pathway Genes: Evolutionary Ancient System Impacting on Human Affiliation, Sociality, and Psychopathology. Biol Psychiatry. 2016 Feb 1;79(3):174-84. doi: 10.1016/j.biopsych.2015.08.008. Epub 2015 Aug 18. Review. PubMed PMID: 26392129.

15: Herpertz SC, Bertsch K. A New Perspective on the Pathophysiology of Borderline Personality Disorder: A Model of the Role of Oxytocin. Am J Psychiatry. 2015 Sep 1;172(9):840-51. doi: 10.1176/appi.ajp.2015.15020216. Review. PubMed PMID: 26324303.

16: Elabd S, Sabry I. Two Birds with One Stone: Possible Dual-Role of Oxytocin in the Treatment of Diabetes and Osteoporosis. Front Endocrinol (Lausanne). 2015 Aug 10;6:121. doi: 10.3389/fendo.2015.00121. eCollection 2015. Review. PubMed PMID: 26322016; PubMed Central PMCID: PMC4530313.

17: Shamay-Tsoory SG, Abu-Akel A. The Social Salience Hypothesis of Oxytocin. Biol Psychiatry. 2016 Feb 1;79(3):194-202. doi: 10.1016/j.biopsych.2015.07.020. Epub 2015 Aug 5. Review. PubMed PMID: 26321019.

18: Altirriba J, Poher AL, Rohner-Jeanrenaud F. Chronic Oxytocin Administration as a Treatment Against Impaired Leptin Signaling or Leptin Resistance in Obesity. Front Endocrinol (Lausanne). 2015 Aug 5;6:119. doi: 10.3389/fendo.2015.00119. eCollection 2015. Review. PubMed PMID: 26300847; PubMed Central PMCID: PMC4525065.

19: Maroun M, Wagner S. Oxytocin and Memory of Emotional Stimuli: Some Dance to Remember, Some Dance to Forget. Biol Psychiatry. 2016 Feb 1;79(3):203-12. doi: 10.1016/j.biopsych.2015.07.016. Epub 2015 Jul 31. Review. PubMed PMID: 26300273.

20: Farina Z, Fawcus S. Oxytocin--ensuring appropriate use and balancing efficacy with safety. S Afr Med J. 2015 Apr;105(4):271-4. Review. PubMed PMID: 26294865.