NCC-149 | CAS#1316652-41-1 | HDAC8 inhibitor

NCC-149
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407293

CAS#: 1316652-41-1

Description: NCC-149 is a HDAC8 inhibitor.

Chemical Structure

NCC-149

CAS# 1316652-41-1

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 407293
Name: NCC-149
CAS#: 1316652-41-1
Chemical Formula: C16H14N4O2S
Exact Mass: 326.08
Molecular Weight: 326.374
Elemental Analysis: C, 58.88; H, 4.32; N, 17.17; O, 9.80; S, 9.82

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NCC-149; NCC 149; NCC149.

IUPAC/Chemical Name: N-hydroxy-3-(1-((phenylthio)methyl)-1H-1,2,3-triazol-4-yl)benzamide

InChi Key: DORPIZJGSLWDIY-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14N4O2S/c21-16(18-22)13-6-4-5-12(9-13)15-10-20(19-17-15)11-23-14-7-2-1-3-8-14/h1-10,22H,11H2,(H,18,21)

SMILES Code: O=C(NO)C1=CC=CC(C2=CN(CSC3=CC=CC=C3)N=N2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot# T21C11I01

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	NCC-149 is a HDAC8 inhibitor.
In vitro activity:	HDAC8-selective inhibitor (NCC-149) (HDAC8i)-treated cells showed smaller EBs than non-treated cells, as well as reduced expression levels of the neuronal marker, NeuN. Reference: Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51. https://pubmed.ncbi.nlm.nih.gov/29499194/
In vivo activity:	TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 326.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	Katayama S, Morii A, Makanga JO, Suzuki T, Miyata N, Inazu T. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51. doi: 10.1016/j.bbrc.2018.02.195. Epub 2018 Feb 28. PMID: 29499194.
In vitro protocol:	Katayama S, Morii A, Makanga JO, Suzuki T, Miyata N, Inazu T. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51. doi: 10.1016/j.bbrc.2018.02.195. Epub 2018 Feb 28. PMID: 29499194.
In vivo protocol:	TBD

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1. Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors. By Tang, Guozhi; Wong, Jason C.; Zhang, Weixing; Wang, Zhanguo; Zhang, Nan; Peng, Zhenghong; Zhang, Zhenshan; Rong, Yiping; Li, Shijie; Zhang, Meifang; et al. From Journal of Medicinal Chemistry (2014), 57(19), 8026-8034.

2. Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8-Selective Inhibitors. By Suzuki, Takayoshi; Muto, Nobusuke; Bando, Masashige; Itoh, Yukihiro; Masaki, Ayako; Ri, Masaki; Ota, Yosuke; Nakagawa, Hidehiko; Iida, Shinsuke; Shirahige, Katsuhiko; et al. From ChemMedChem (2014), 9(3), 657-664.

3. Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries. Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; et al. From Journal of Medicinal Chemistry (2012), 55(22), 9562-9575.

4. Preparation of hydroxamic acid derivatives as HDAC8 inhibitors. By Miyata, Naoki; Suzuki, Takayoshi; Ota, Yosuke; Ueda, Ryuzo; Iida, Shinsuke; Ri, Masaki. From PCT Int. Appl. (2011), WO 2011089995 A1 20110728.

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