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MedKoo CAT#: 407291

CAS#: 949727-86-0

Description: T5979345 is a HDAC8 inhibitor. S. mansoni histone deacetylase 8 (smHDAC8) as a potential target for antiparasitic therapy.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-07. Prices are subject to change without notice.

T5979345 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international). Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 407291
Name: T5979345
CAS#: 949727-86-0
Chemical Formula: C10H10N2O3S
Exact Mass: 238.0412
Molecular Weight: 238.261
Elemental Analysis: C, 50.41; H, 4.23; N, 11.76; O, 20.14; S, 13.46

Synonym: T5979345, T-5979345, T 5979345

IUPAC/Chemical Name: N-hydroxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide


InChi Code: InChI=1S/C10H10N2O3S/c1-5-9(13)11-7-4-6(10(14)12-15)2-3-8(7)16-5/h2-5,15H,1H3,(H,11,13)(H,12,14)

SMILES Code: O=C(C1=CC=C(SC(C)C(N2)=O)C2=C1)NO

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1. Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation. By Kannan, Srinivasaraghavan; Melesina, Jelena; Hauser, Alexander-Thomas; Chakrabarti, Alokta; Heimburg, Tino; Schmidtkunz, Karin; Walter, Alexandra; Marek, Martin; Pierce, Raymond J.; Romier, Christophe; et al. From Journal of Chemical Information and Modeling (2014), 54(10), 3005-3019.

2. Structural basis for the inhibition of histone deacetylase 8 (HDAC8)​, a key epigenetic player in the blood fluke Schistosoma mansoni. By Marek, Martin; Kannan, Srinivasaraghavan; Hauser, Alexander-Thomas; Mourao, Marina Moraes; Caby, Stephanie; Cura, Vincent; Stolfa, Diana A.; Schmidtkunz, Karin; Lancelot, Julien; Andrade, Luiza; et al. From PLoS Pathogens (2013), 9(9), e1003645. | Language: English, Database: CAPLUS