Hydroflumethiazide
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MedKoo CAT#: 317999

CAS#: 135-09-1

Description: Hydroflumethiazide is a thiazide diuretic with actions. It is also an anti-hypertensive and a diuretic.The physiologic effect of hydroflumethiazide is by means of increased diuresis.


Chemical Structure

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Hydroflumethiazide
CAS# 135-09-1

Theoretical Analysis

MedKoo Cat#: 317999
Name: Hydroflumethiazide
CAS#: 135-09-1
Chemical Formula: C8H8F3N3O4S2
Exact Mass: 330.99
Molecular Weight: 331.290
Elemental Analysis: C, 29.00; H, 2.43; F, 17.20; N, 12.68; O, 19.32; S, 19.36

Price and Availability

Size Price Availability Quantity
100mg USD 450 2 Weeks
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Synonym: Hydroflumethiazide; Diuredemina; Glomerulin; Hidroflumetiazid; Diurometon; Flutizide;

IUPAC/Chemical Name: 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

InChi Key: DMDGGSIALPNSEE-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)

SMILES Code: C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 331.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ogola EN, Yonga GO. Comparative study of the efficacy and tolerability of
hydroflumethiazide versus propranolol in Africans with mild to moderate
hypertension. East Afr Med J. 1993 May;70(5):277-9. PubMed PMID: 8306902.


2: Agrawal YK, Giridhar R, Menon SK. Spectrophotometric determination of
hydroflumethiazide. J Pharm Biomed Anal. 1989;7(6):759-63. PubMed PMID: 2490778.


3: Hermansen K, Schmitz O, Mogensen CE. Effects of a thiazide diuretic
(hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas:
studies in vitro. Metabolism. 1985 Aug;34(8):784-9. PubMed PMID: 2862565.


4: Corrigan OI, Holohan EM. Amorphous spray-dried
hydroflumethiazide-polyvinylpyrrolidone systems: physiochemical properties. J
Pharm Pharmacol. 1984 Apr;36(4):217-21. PubMed PMID: 6144766.


5: Brørs O, Braut GS, Braut S, Jacobsen S. Interaction of hydroflumethiazide and
2,4-disulfamyl-5-trifluoromethylaniline with cyclic AMP phosphodiesterase and
carbonic anhydrase. Acta Pharmacol Toxicol (Copenh). 1982 Oct;51(4):273-7. PubMed
PMID: 6295063.


6: Brørs O, Jacobsen S. Distribution of elimination of hydroflumethiazide in man.
Eur J Clin Pharmacol. 1979 Sep;16(2):125-31. PubMed PMID: 499309.


7: Brørs O, Jacobsen S. Pharmacokinetics of hydroflumethiazide during repeated
oral administration to healthy subjects. Eur J Clin Pharmacol. 1979 May
21;15(4):281-6. PubMed PMID: 477713.


8: McNamara PJ, Colburn WA, Gibaldi M. Absorption kinetics of hydroflumethiazide.
J Clin Pharmacol. 1978 Apr;18(4):190-3. PubMed PMID: 632365.


9: Owen BJ, Wilkie SV. Separation and quantitative determination of
2,4-disulfamyl-5-trifluoromethylaniline in hydroflumethiazide using high-pressure
liquid chromatography. J Pharm Sci. 1977 Jun;66(6):877-8. PubMed PMID: 874795.


10: Smith RB, Smith RV, Yakatan GJ. Spectrofluorometric determination of
hydroflumethiazide in plasma and urine. J Pharm Sci. 1976 Aug;65(8):1208-11.
PubMed PMID: 10417.


11: Corrigan OI, Timoney RF. Anomalous behavior of some hydroflumethiazide
crystal samples. J Pharm Pharmacol. 1974 Oct;26(10):838-40. PubMed PMID: 4156551.


12: Kjaerulff J, Lyngsoe J. [The antihypertensive effects of bendroflumethiazide,
hydroflumethiazide, trichlormethiazide, chlorthalidone and furosemide]. Ugeskr
Laeger. 1973 Aug 13;135(33):1744-6. Danish. PubMed PMID: 4777951.


13: Agren A, Bäck T. Complex formation between macromolecules and drugs. 8.
Binding of saccharine, N-methyl saccharine, and the diuretic drugs
hydroflumethiazide and bendroflumethiazide to human serum albumin. Acta Pharm
Suec. 1973 Jun;10(3):223-8. PubMed PMID: 4729699.


14: Nishioeda Y. [Effect of hydroflumethiazide on the kinetics of thyroxine in
the blood]. Nihon Naibunpi Gakkai Zasshi. 1972 Jul 20;48(4):245-59. Japanese.
PubMed PMID: 4626614.


15: A spironolactone-hydroflumethiazide combination in hypertension.
Practitioner. 1971 Mar;206(233):412-5. PubMed PMID: 4929196.


16: Jamil MA. A comparative study of spironolactone and hydroflumethiazide alone
and together in the treatment of hypertension. Guys Hosp Rep. 1971;120(3):207-19.
PubMed PMID: 4951058.


17: Williamson JM, Neilson FJ, Gibbs WN. Hypoplastic anaemia and
hydroflumethiazide. Scott Med J. 1966 Jan;11(1):19-20. PubMed PMID: 5905311.


18: PISANI E, BOSELLI G. [Clinical research with a new diuretic:
hydroflumethiazide potassium salt]. Minerva Med. 1962 Oct 24;53:3159-62. Italian.
PubMed PMID: 13943783.


19: VERTES V, KATZ JB, ROBINOW SH. Comparison of short term metabolic effects of
hydroflumethiazide and hydrochlorothiazide. J Chronic Dis. 1962 Feb;15:171-7.
PubMed PMID: 13925585.


20: GILLHESPY RO. The antihypertensive activity of hydroflumethiazide with
Rauwolfia. J Ir Med Assoc. 1962 Feb;50:49-50. PubMed PMID: 13898651.