SGC707
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MedKoo CAT#: 407283

CAS#: 1687736-54-4

Description: SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 is a potent PRMT3 inhibitor (IC50 =31±2 nM, KD =53±2 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets). The mechanism of action studies and crystal structure of the PRMT3-SGC707 complex confirm the allosteric inhibition mode. Importantly, SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.


Price and Availability

Size
Price

10mg
USD 120
100mg
USD 650
1g
USD 2450
Size
Price

25mg
USD 250
200mg
USD 950
2g
USD 3850
Size
Price

50mg
USD 450
500mg
USD 1750
5g
Ask price

SGC707, purity > 98%, is in stock Current shipping out time is about 2 weeks after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407283
Name: SGC707
CAS#: 1687736-54-4
Chemical Formula: C16H18N4O2
Exact Mass: 298.143
Molecular Weight: 298.346
Elemental Analysis: C, 64.41; H, 6.08; N, 18.78; O, 10.73


Synonym: SGC707; SGC-707; SGC 707.

IUPAC/Chemical Name: N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea

SMILES Code: O=C(NCC(N1CCCC1)=O)NC2=CC3=C(C=NC=C3)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He
F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon
M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D,
Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi M. A potent, selective and
cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).
Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. doi: 10.1002/anie.201412154.
Epub 2015 Feb 27. PubMed PMID: 25728001; PubMed Central PMCID: PMC4400258.