OF-1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407282

CAS#: 19973-83-4

Description: OF-1 is a chemical probe for BRPF bromodomains. OF-1 has been shown to bind to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 uM (ITC). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 µM in the alphascreen). OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 µM and also demonstrates accelerated FRAP recovery at 5 µM in the BRPF2 FRAP assay. It shows modest general cytotoxicity. (http://www.thesgc.org/chemical-probes/OF-1).


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 850
1g
USD 2950
Size
Price

25mg
USD 250
200mg
USD 1450
2g
USD 4650
Size
Price

50mg
USD 450
500mg
USD 2150
5g
Ask price

OF-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407282
Name: OF-1
CAS#: 19973-83-4
Chemical Formula: C17H18BrN3O4S
Exact Mass: 439.0201
Molecular Weight: 440.312
Elemental Analysis: C, 46.37; H, 4.12; Br, 18.15; N, 9.54; O, 14.53; S, 7.28


Synonym: OF-1; OF1; OF 1.

IUPAC/Chemical Name: 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide

InChi Key: YUNQZQREIHWDQT-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3

SMILES Code: O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490