WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407282
Description: OF-1 is a chemical probe for BRPF bromodomains. OF-1 has been shown to bind to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 uM (ITC). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 µM in the alphascreen). OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 µM and also demonstrates accelerated FRAP recovery at 5 µM in the BRPF2 FRAP assay. It shows modest general cytotoxicity. (http://www.thesgc.org/chemical-probes/OF-1).
MedKoo Cat#: 407282
Chemical Formula: C17H18BrN3O4S
Exact Mass: 439.0201
Molecular Weight: 440.312
Elemental Analysis: C, 46.37; H, 4.12; Br, 18.15; N, 9.54; O, 14.53; S, 7.28
Synonym: OF-1; OF1; OF 1.
IUPAC/Chemical Name: 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide
InChi Key: YUNQZQREIHWDQT-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
SMILES Code: O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O