Hexachlorophene
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317991

CAS#: 70-30-4

Description: Hexachlorophene is a chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. It is also used in agriculture as a soil fungicide, plant bactericide, and acaricide.


Chemical Structure

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Hexachlorophene
CAS# 70-30-4

Theoretical Analysis

MedKoo Cat#: 317991
Name: Hexachlorophene
CAS#: 70-30-4
Chemical Formula: C13H6Cl6O2
Exact Mass: 403.85
Molecular Weight: 406.900
Elemental Analysis: C, 38.37; H, 1.49; Cl, 52.28; O, 7.86

Price and Availability

Size Price Availability Quantity
1g USD 350 2 Weeks
2g USD 550 2 Weeks
5g USD 1250 2 Weeks
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Synonym: Hexachlorophene; Hexachlorofen; Hexachlorophen; Almederm; Distodin;

IUPAC/Chemical Name: 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol

InChi Key: ACGUYXCXAPNIKK-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H6Cl6O2/c14-6-2-8(16)12(20)4(10(6)18)1-5-11(19)7(15)3-9(17)13(5)21/h2-3,20-21H,1H2

SMILES Code: C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 406.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kato M, Abe H, Itahashi M, Kikuchihara Y, Kimura M, Mizukami S, Yoshida T,
Shibutani M. Maternal exposure to hexachlorophene targets intermediate-stage
progenitor cells in the hippocampal neurogenesis involving myelin vacuolation of
cholinergic and glutamatergic inputs in mice. J Appl Toxicol. 2016
Feb;36(2):211-22. doi: 10.1002/jat.3162. Epub 2015 May 5. PubMed PMID: 25943520.


2: Narayan M, Peralta DA, Gibson C, Zitnyar A, Jinwal UK. An optimized InCell
Western screening technique identifies hexachlorophene as a novel potent TDP43
targeting drug. J Biotechnol. 2015 Aug 10;207:34-8. doi:
10.1016/j.jbiotec.2015.04.012. Epub 2015 May 16. PubMed PMID: 25987361.


3: Itahashi M, Abe H, Tanaka T, Mizukami S, Kimura M, Yoshida T, Shibutani M.
Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells
of the hippocampal neurogenesis in rat offspring via dysfunction of cholinergic
inputs by myelin vacuolation. Toxicology. 2015 Feb 3;328:123-34. doi:
10.1016/j.tox.2014.12.009. Epub 2014 Dec 11. PubMed PMID: 25497112.


4: Erdos Z, Pearson K, Goedken M, Menzel K, Sistare FD, Glaab WE, Saldutti LP.
Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane
sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha
ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in
male rats. Birth Defects Res B Dev Reprod Toxicol. 2013 Feb;98(1):41-53. doi:
10.1002/bdrb.21035. Epub 2013 Jan 24. PubMed PMID: 23348767.


5: Kanno T, Sasaki S, Yamada N, Kawasako K, Tsuchitani M. Hexachlorophene and
cuprizone induce the spongy change of the developing rat brain by different
mechanisms: the role of 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase). J
Vet Med Sci. 2012 Jul;74(7):837-43. Epub 2012 Feb 8. PubMed PMID: 22313968.


6: Miller LG, Tan J, Eells SJ, Benitez E, Radner AB. Prospective investigation of
nasal mupirocin, hexachlorophene body wash, and systemic antibiotics for
prevention of recurrent community-associated methicillin-resistant Staphylococcus
aureus infections. Antimicrob Agents Chemother. 2012 Feb;56(2):1084-6. doi:
10.1128/AAC.01608-10. Epub 2011 Nov 14. PubMed PMID: 22083485; PubMed Central
PMCID: PMC3264243.


7: Zheng Y, Zhu X, Zhou P, Lan X, Xu H, Li M, Gao Z. Hexachlorophene is a potent
KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. PLoS One.
2012;7(12):e51820. doi: 10.1371/journal.pone.0051820. Epub 2012 Dec 12. PubMed
PMID: 23251633; PubMed Central PMCID: PMC3520906.


8: Min HJ, Cho IR, Srisuttee R, Park EH, Cho DH, Ahn JH, Lee IS, Johnston RN, Oh
S, Chung YH. Hexachlorophene suppresses beta-catenin expression by up-regulation
of Siah-1 in EBV-infected B lymphoma cells. Cancer Lett. 2009 Apr
18;276(2):136-42. doi: 10.1016/j.canlet.2008.10.041. Epub 2008 Dec 16. PubMed
PMID: 19091460.


9: Park S, Gwak J, Cho M, Song T, Won J, Kim DE, Shin JG, Oh S. Hexachlorophene
inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin
degradation. Mol Pharmacol. 2006 Sep;70(3):960-6. Epub 2006 May 30. PubMed PMID:
16735606.


10: Marcinkeviciene J, Jiang W, Kopcho LM, Locke G, Luo Y, Copeland RA. Enoyl-ACP
reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and
inhibition by triclosan and hexachlorophene. Arch Biochem Biophys. 2001 Jun
1;390(1):101-8. Erratum in: Arch Biochem Biophys 2001 Dec 15;396(2):249. PubMed
PMID: 11368521.


11: Kinoshita Y, Matsumura H, Igisu H, Yokota A. Hexachlorophene-induced brain
edema in rat observed by proton magnetic resonance. Brain Res. 2000 Aug
4;873(1):127-30. PubMed PMID: 10915818.


12: Häntzschel A, Andreas K. Efficacy of glutamate receptor antagonists in the
management of functional disorders in cytotoxic brain oedema induced by
hexachlorophene. Pharmacol Toxicol. 1998 Feb;82(2):80-8. PubMed PMID: 9498236.


13: Matsumura H, Matsuoka M, Igisu H, Ikeda M. Cooperative inhibition of
acetylcholinesterase activities by hexachlorophene in human erythrocytes. Arch
Toxicol. 1997;71(3):151-6. PubMed PMID: 9049051.


14: Flanagan RJ, Ruprah M, Strutt AV, Malarkey P, Cockburn A. Effect of urinary
alkalinisation and acidification on the tissue distribution of hexachlorophene in
rats. Hum Exp Toxicol. 1995 Oct;14(10):795-800. PubMed PMID: 8562119.


15: Reasor MJ, Montgomery MR. Hexachlorophene exposure in a young patient with
soft tissue sarcoma. Br J Ind Med. 1993 Jul;50(7):670. PubMed PMID: 8343430;
PubMed Central PMCID: PMC1035506.


16: Andreas K, Blaschke M, Bergsträsser E, Fischer HD, Schmidt J. Neurochemical
characterization of hexachlorophene induced brain oedema. Arch Toxicol Suppl.
1991;14:30-2. PubMed PMID: 1839603.


17: Poppenga RH, Trapp AL, Braselton WE, Louden CG, Gumbs JM, Dalley JB.
Hexachlorophene toxicosis in a litter of Doberman pinschers. J Vet Diagn Invest.
1990 Apr;2(2):129-31. PubMed PMID: 2094434.


18: Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ,
Roth JA. Effect of short-term exposure to hexachlorophene on rat brain cell
specific marker enzymes. Fundam Appl Toxicol. 1988 Oct;11(3):519-27. PubMed PMID:
2906023.


19: Rajendra W, Prasad GV, Indira K. Deviations in hepatic amino acid profiles of
mouse following repeated hexachlorophene administration. J Environ Sci Health B.
1988 Aug;23(4):409-26. PubMed PMID: 3192908.


20: Vorherr H, Vorherr UF, Moss JC. Comparative effectiveness of chlorhexidine,
povidone-iodine, and hexachlorophene on the bacteria of the perineum and groin of
pregnant women. Am J Infect Control. 1988 Aug;16(4):178-81. PubMed PMID: 3189944.