Isothipendyl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318075

CAS#: 482-15-5

Description: Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic.

Chemical Structure

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Isothipendyl
CAS# 482-15-5
Instruction

Theoretical Analysis

MedKoo Cat#: 318075
Name: Isothipendyl
CAS#: 482-15-5
Chemical Formula: C16H19N3S
Exact Mass: 285.13
Molecular Weight: 285.407
Elemental Analysis: C, 67.33; H, 6.71; N, 14.72; S, 11.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Isothipendyl, Nilergex, Andanton, Odantol, Udantol, Isothipendylum

IUPAC/Chemical Name: N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine

InChi Key: OQJBSDFFQWMKBQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19N3S/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19/h4-10,12H,11H2,1-3H3

SMILES Code: CC(N(C)C)CN1C2=NC=CC=C2SC3=CC=CC=C13

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 285.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bibas N, Sartor V, Bulai Livideanu C, Bagheri H, Nougué J, Giordano-Labadie F, Maza A, Paul C, Chouini-Lalanne N, Marguery MC. Contact photoallergy to isothipendyl chlorhydrate. Dermatology. 2012;224(4):289-91. doi: 10.1159/000338024. Epub 2012 Jun 1. PubMed PMID: 22677929.

2: Melwanki MB, Seetharamappa J, Masti SP. Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples. Anal Sci. 2001 Sep;17(9):1121-3. PubMed PMID: 11708072.

3: Moreau A, Dompmartin A, Dubreuil A, Leroy D. Phototoxic and photoprotective effects of topical isothipendyl. Photodermatol Photoimmunol Photomed. 1995 Apr;11(2):50-4. PubMed PMID: 8546983.

4: Abdel-Hay MH, Elsayed MA, Barary MH, Hassan EM. Determination of isothipendyl or dimethothiazine with their sulphoxides using third- and fourth-derivatives spectroscopy on a diode-array spectrophotometer. J Pharm Belg. 1990 Jul-Aug;45(4):259-67. PubMed PMID: 2290121.

5: Takashima Y, Tanaka S, Hosono S, Kawamata I, Murayama H. [Distribution of isothipendyl in O/W type creams and its release]. Yakugaku Zasshi. 1985 Feb;105(2):166-70. Japanese. PubMed PMID: 2861270.

6: Takashima A, Yoshikawa K. Contact allergy to isothipendyl. Contact Dermatitis. 1983 Sep;9(5):429-30. PubMed PMID: 6138212.

7: Bartsch W, Dietmann K, Nothdurft H. [Pharmacologic experience on the effects of antihistaminic isothipendyl hydrochloride combined with calcium gluconate]. Hospital (Rio J). 1969 Jan;75(1):187-99. Portuguese. PubMed PMID: 4387989.

8: UHR L, MILLER JG. An experimental study of the behavioral effects of isothipendyl hydrochloride (Theruhistin). Acta Allergol. 1961;16:141-50. PubMed PMID: 13779032.

9: ALEXANDER JO, HARVEY G. A clinical trial of isothipendyl hydrochloride (nilergex) in dermatology. Scott Med J. 1960 Apr;5:158-61. PubMed PMID: 13792589.

10: CLINICAL evaluation of isothipendyl hydrochloride (theruhistin); report of the Committee on New and Unused Therapeutics. Ann Allergy. 1958 May-Jun;16(3):237-41. PubMed PMID: 13545696.