NBI-34041

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MedKoo CAT#: 522654

CAS#: 268545-87-5

Description: NBI-34041 is potent and high-affinity CRF1 receptor antagonist. NBI-34041 is safety and efficacy in attenuating elevated stress response. NBI-34041 is effective in reducing endocrine responses to pharmacological and behavioral challenge mediated by CRF(1) receptors. NBI-34041 is safe and does not impair basal regulation of the HPA system but improves resistance against psychosocial stress. NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders.


Price and Availability

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Pricing updated 2020-03-28. Prices are subject to change without notice.

NBI-34041 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522654
Name: NBI-34041
CAS#: 268545-87-5
Chemical Formula: C22H26Cl2N4
Exact Mass: 416.1535
Molecular Weight: 417.378
Elemental Analysis: C, 63.31; H, 6.28; Cl, 16.99; N, 13.42


Synonym: NBI-34041; NBI 34041; NBI34041; SB-723620; SB723620; SB 723620

IUPAC/Chemical Name: 1-(2,4-dichlorophenyl)-5-(heptan-4-yl)-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene

InChi Key: AKFWXFDMKRSYRD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N4O3/c1-7-10-25(11-12-27-4)20-13-15(2)23-22-21(16(3)24-26(20)22)18-9-8-17(28-5)14-19(18)29-6/h8-9,13-14H,7,10-12H2,1-6H3

SMILES Code: CCCC(N1C2=C3N(N=C(C4=CC=C(Cl)C=C4Cl)C3=NC(C)=C2)CC1)CCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Steckler T. Developing small molecule nonpeptidergic drugs for the treatment
of anxiety disorders: is the challenge still ahead? Curr Top Behav Neurosci.
2010;2:415-28. Review. PubMed PMID: 21309119.

2: Holsboer F, Ising M. Central CRH system in depression and anxiety--evidence
from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol. 2008 Apr
7;583(2-3):350-7. doi: 10.1016/j.ejphar.2007.12.032. Epub 2008 Jan 24. Review.
PubMed PMID: 18272149.

3: Ising M, Holsboer F. CRH-sub-1 receptor antagonists for the treatment of
depression and anxiety. Exp Clin Psychopharmacol. 2007 Dec;15(6):519-28. doi:
10.1037/1064-1297.15.6.519. Review. PubMed PMID: 18179304.

4: Ising M, Zimmermann US, Künzel HE, Uhr M, Foster AC, Learned-Coughlin SM,
Holsboer F, Grigoriadis DE. High-affinity CRF1 receptor antagonist NBI-34041:
preclinical and clinical data suggest safety and efficacy in attenuating elevated
stress response. Neuropsychopharmacology. 2007 Sep;32(9):1941-9. Epub 2007 Feb 7.
PubMed PMID: 17287823.