NBI-34041

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522654

CAS#: 268545-87-5

Description: NBI-34041 is potent and high-affinity CRF1 receptor antagonist. NBI-34041 is safety and efficacy in attenuating elevated stress response. NBI-34041 is effective in reducing endocrine responses to pharmacological and behavioral challenge mediated by CRF(1) receptors. NBI-34041 is safe and does not impair basal regulation of the HPA system but improves resistance against psychosocial stress. NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders.


Chemical Structure

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NBI-34041
CAS# 268545-87-5

Theoretical Analysis

MedKoo Cat#: 522654
Name: NBI-34041
CAS#: 268545-87-5
Chemical Formula: C22H26Cl2N4
Exact Mass: 416.1535
Molecular Weight: 417.378
Elemental Analysis: C, 63.31; H, 6.28; Cl, 16.99; N, 13.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NBI-34041; NBI 34041; NBI34041; SB-723620; SB723620; SB 723620

IUPAC/Chemical Name: 1-(2,4-dichlorophenyl)-5-(heptan-4-yl)-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene

InChi Key: AKFWXFDMKRSYRD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N4O3/c1-7-10-25(11-12-27-4)20-13-15(2)23-22-21(16(3)24-26(20)22)18-9-8-17(28-5)14-19(18)29-6/h8-9,13-14H,7,10-12H2,1-6H3

SMILES Code: CCCC(N1C2=C3N(N=C(C4=CC=C(Cl)C=C4Cl)C3=NC(C)=C2)CC1)CCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 417.378 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Steckler T. Developing small molecule nonpeptidergic drugs for the treatment
of anxiety disorders: is the challenge still ahead? Curr Top Behav Neurosci.
2010;2:415-28. Review. PubMed PMID: 21309119.

2: Holsboer F, Ising M. Central CRH system in depression and anxiety--evidence
from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol. 2008 Apr
7;583(2-3):350-7. doi: 10.1016/j.ejphar.2007.12.032. Epub 2008 Jan 24. Review.
PubMed PMID: 18272149.

3: Ising M, Holsboer F. CRH-sub-1 receptor antagonists for the treatment of
depression and anxiety. Exp Clin Psychopharmacol. 2007 Dec;15(6):519-28. doi:
10.1037/1064-1297.15.6.519. Review. PubMed PMID: 18179304.

4: Ising M, Zimmermann US, Künzel HE, Uhr M, Foster AC, Learned-Coughlin SM,
Holsboer F, Grigoriadis DE. High-affinity CRF1 receptor antagonist NBI-34041:
preclinical and clinical data suggest safety and efficacy in attenuating elevated
stress response. Neuropsychopharmacology. 2007 Sep;32(9):1941-9. Epub 2007 Feb 7.
PubMed PMID: 17287823.