WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522645
Description: AM-0902 is a potent and selective Transient Receptor Potential A1 (TRPA1) Antagonist Demonstrating Potent in Vivo Activity with pharmacokinetic properties allowing for >30-fold coverage of the rat TRPA1 IC50 in vivo. AM-0902 showed rTRPA1 45Ca2+ Flux IC50=0.071 microM and hTRPA1 45Ca2+ Flux IC50=0.131 microM. AM-0902 demonstrated dose-dependent inhibition of AITC-induced flinching in rats, validating its utility as a tool for interrogating the role of TRPA1 in in vivo pain models.
MedKoo Cat#: 522645
Chemical Formula: C17H15ClN6O2
Exact Mass: 370.0945
Molecular Weight: 370.797
Elemental Analysis: C, 55.07; H, 4.08; Cl, 9.56; N, 22.67; O, 8.63
Synonym: AM-0902; AM 0902; AM0902.
IUPAC/Chemical Name: 1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one
InChi Key: AWJBWNUUODWOKQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3
SMILES Code: O=C1N(CC2=NC(CCC3=CC=C(Cl)C=C3)=NO2)C=NC4=C1N(C)C=N4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 370.797 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity
Laurie B. Schenkel, Philip R. Olivieri, Alessandro A. Boezio, Holly L. Deak, Renee Emkey, Russell F. Graceffa, Hakan Gunaydin, Angel Guzman-Perez, Josie H. Lee, Yohannes Teffera, Weiya Wang, Beth D. Youngblood, Violeta L. Yu, Maosheng Zhang, Narender R. Gavva, Sonya G. Lehto, and Stephanie Geuns-Meye. Publication Date (Web): March 4, 2016 (Article); DOI: 10.1021/acs.jmedchem.6b00039