AM-0902
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MedKoo CAT#: 522645

CAS#: 1883711-97-4

Description: AM-0902 is a potent and selective Transient Receptor Potential A1 (TRPA1) Antagonist Demonstrating Potent in Vivo Activity with pharmacokinetic properties allowing for >30-fold coverage of the rat TRPA1 IC50 in vivo. AM-0902 showed rTRPA1 45Ca2+ Flux IC50=0.071 microM and hTRPA1 45Ca2+ Flux IC50=0.131 microM. AM-0902 demonstrated dose-dependent inhibition of AITC-induced flinching in rats, validating its utility as a tool for interrogating the role of TRPA1 in in vivo pain models.


Chemical Structure

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AM-0902
CAS# 1883711-97-4

Theoretical Analysis

MedKoo Cat#: 522645
Name: AM-0902
CAS#: 1883711-97-4
Chemical Formula: C17H15ClN6O2
Exact Mass: 370.0945
Molecular Weight: 370.797
Elemental Analysis: C, 55.07; H, 4.08; Cl, 9.56; N, 22.67; O, 8.63

Price and Availability

Size Price Availability Quantity
25.0mg USD 250.0 Same Day
50.0mg USD 450.0 Same Day
100.0mg USD 750.0 Same Day
200.0mg USD 1250.0 Same Day
500.0mg USD 1950.0 Same Day
1.0g USD 3150.0 2 Weeks
2.0g USD 5450.0 2 Weeks
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Synonym: AM-0902; AM 0902; AM0902.

IUPAC/Chemical Name: 1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one

InChi Key: AWJBWNUUODWOKQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3

SMILES Code: O=C1N(CC2=NC(CCC3=CC=C(Cl)C=C3)=NO2)C=NC4=C1N(C)C=N4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 370.797 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity
Laurie B. Schenkel, Philip R. Olivieri, Alessandro A. Boezio, Holly L. Deak, Renee Emkey, Russell F. Graceffa, Hakan Gunaydin, Angel Guzman-Perez, Josie H. Lee, Yohannes Teffera, Weiya Wang, Beth D. Youngblood, Violeta L. Yu, Maosheng Zhang, Narender R. Gavva, Sonya G. Lehto, and Stephanie Geuns-Meye. Publication Date (Web): March 4, 2016 (Article); DOI: 10.1021/acs.jmedchem.6b00039

AM-0902

25.0mg / USD 250.0