Isoetharine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318069

CAS#: 530-08-5 (free base)

Description: Isoetharine is a selective beta2-adrenergic receptor agonist. It is used as a bronchodilator for emphysema, bronchitis and asthma.


Chemical Structure

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Isoetharine
CAS# 530-08-5 (free base)

Theoretical Analysis

MedKoo Cat#: 318069
Name: Isoetharine
CAS#: 530-08-5 (free base)
Chemical Formula: C13H21NO3
Exact Mass: 239.15
Molecular Weight: 239.311
Elemental Analysis: C, 65.25; H, 8.84; N, 5.85; O, 20.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 7279-75-6 (mesylate)   530-08-5 (free base)    

Synonym: Isoetharine, Isoetarine, Bronkosol, Bronkometer, Etyprenalinum

IUPAC/Chemical Name: 4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol

InChi Key: HUYWAWARQUIQLE-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H21NO3/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9/h5-8,10,13-17H,4H2,1-3H3

SMILES Code: OC1=CC=C(C(O)C(NC(C)C)CC)C=C1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 239.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shrestha M, Gourlay S, Robertson S, Bidadi K, Wainscott M, Hayes J. Isoetharine versus albuterol for acute asthma: greater immediate effect, but more side effects. Am J Med. 1996 Mar;100(3):323-7. PubMed PMID: 8629678.

2: Emerman CL, Cydulka RK, Effron D, Lukens TW, Gershman H, Boehm SP. A randomized, controlled comparison of isoetharine and albuterol in the treatment of acute asthma. Ann Emerg Med. 1991 Oct;20(10):1090-3. PubMed PMID: 1928879.

3: Lew DB, Herrod HG, Crawford LV. Combination of atropine and isoetharine aerosol therapy in pediatric acute asthma. Ann Allergy. 1990 Feb;64(2 Pt 2):195-200. PubMed PMID: 2301781.

4: Casthely PA, Cottrell JE, Urquhart PA. Comparison of metaproterenol, isoetharine and salbutamol in the relief of methacholine-induced bronchospasm in dogs. Can Anaesth Soc J. 1985 Mar;32(2):112-8. PubMed PMID: 3886091.

5: Koepke JW, Christopher KL, Chai H, Selner JC. Dose-dependent bronchospasm from sulfites in isoetharine. JAMA. 1984 Jun 8;251(22):2982-3. PubMed PMID: 6716626.

6: Peerless AG, Rachelefsky GS, Mickey MR, Katz RM, Siegel SC. Bronchodilator characteristics of nebulized metaproterenol sulfate, isoetharine, and atropine in chronic asthma. J Allergy Clin Immunol. 1983 Dec;72(6):702-8. PubMed PMID: 6358329.

7: König P, Hurst DJ. Nebulized isoetharine and fenoterol in acute attacks of asthma. Arch Intern Med. 1983 Jul;143(7):1361-4. PubMed PMID: 6347110.

8: Spellman GG Jr, Gruebel BJ, Epstein JD, Rotman HH, Weg JG. Comparison of fenoterol, isoproterenol, and isoetharine with phenylephrine aerosol in asthma. J Clin Pharmacol. 1983 Feb-Mar;23(2-3):82-8. PubMed PMID: 6853746.

9: Twarog FJ, Leung DY. Anaphylaxis to a component of isoetharine (sodium bisulfite). JAMA. 1982 Oct 22;248(16):2030-1. PubMed PMID: 7120631.

10: Yates T, Dubin B, Bell-Jesion C. A comparison of isoetharine and albuterol: report of changes in pulmonary functions over 1 hour. J Am Osteopath Assoc. 1982 Apr;81(8):546-8. PubMed PMID: 7042663.

11: Sinha BN, Allan GW, Lees AW. Oral orciprenaline, salbutamol and isoetharine compared. Br J Dis Chest. 1973 Jan;67(1):61-5. PubMed PMID: 4143896.

12: Strunge B. [Sustained-release isoetharine. The bronchodilating effect compared with orciprenaline and placebos in a double-blind study]. Ugeskr Laeger. 1972 Jul 3;134(27):1432-4. Danish. PubMed PMID: 4562049.

13: Jensen V. [Bronchodilator effect of oral isoetharine and isoprenaline inhalation]. Nord Med. 1971 Jun 17;85(24):745-8. Danish. PubMed PMID: 4933262.

14: Jensen V. [Broncholytic effect of isoetharine per os and inhalation of isoprenaline]. Nord Med. 1971 Jun 10;85(23):728. Norwegian. PubMed PMID: 5089019.

15: Chapman TT, De Wytt C. Isoetharine and salbutamol--a comparative bronchodilator trial. J Ir Med Assoc. 1971 Mar 4;64(407):137-40. PubMed PMID: 4932017.

16: Thiringer G, Bergh NP, Svedmyr N. A comparative study of the effects of isoetharine and some other adrenergic beta-stimulators in chronic obstructive lung disease. Scand J Respir Dis. 1971;52(4):183-91. PubMed PMID: 5161421.

17: Howard LA, Coleman M. A crossover comparison of isoproterenol, metaproterenol and isoetharine by spirometric determinations. Ann Allergy. 1967 Sep;25(9):512-9. PubMed PMID: 4861327.

18: Unger DL, Unger L. Isoetharine methanesulfonate with phenylephrine hydrochloride and thenyldiamine (Bronkometer) in hypertensive and sympathomimetic amine-sensitive asthmatic patients. Dis Chest. 1967 Feb;51(2):153-5. PubMed PMID: 4381226.

19: LANDS AM. Absorption profile of the bronchodilator drug, isoetharine. Arch Int Pharmacodyn Ther. 1962 Aug 1;138:462-72. PubMed PMID: 13928488.

20: LANDS AM, LUDUENA FP, HOPPE JO, OYEN IH. The pharmacologic actions of the bronchodilator drug, isoetharine. J Am Pharm Assoc Am Pharm Assoc. 1958 Oct;47(10):744-8. PubMed PMID: 13587307.