WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407266

CAS#: Unknown (Palbociclib-SMCC)

Description: Palbociclib-SMCC is a Palbociclib derivative with a SMCC linker. Palbociclib-SMCC is useful to make Palbociclib drug conjugate (Antibody-drug conjugate, ADC) for targeted drug delivery. Palbociclib is an cyclin-dependent kinase (CDK) inhibitor. Palbociclib was approved in 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor-positive advanced breast cancer.

Price and Availability




Palbociclib-SMCC is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 407266
Name: Palbociclib-SMCC
CAS#: Unknown (Palbociclib-SMCC)
Chemical Formula: C36H42N8O5
Exact Mass: 666.3278
Molecular Weight: 666.783
Elemental Analysis: C, 64.85; H, 6.35; N, 16.81; O, 12.00

Related CAS #: 571190-30-2 (free base) 827022-32-2 (HCl) 827022-33-3 (isethionate)   Unknown (Palbociclib-SMCC)    

Synonym: PD0332991-SMCC; PD 0332991-SMCC; PD-0332991-SMCC; Palbociclib-SMCC; Palbociclib-SMCC linker; Palbociclib with a SMCC linker. Palbociclib conjugate.

IUPAC/Chemical Name: 1-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carbonyl)cyclohexyl)methyl)-1H-pyrrole-2,5-dione


InChi Code: InChI=1S/C36H42N8O5/c1-22-28-20-38-36(40-33(28)44(26-5-3-4-6-26)35(49)32(22)23(2)45)39-29-12-11-27(19-37-29)41-15-17-42(18-16-41)34(48)25-9-7-24(8-10-25)21-43-30(46)13-14-31(43)47/h11-14,19-20,24-26H,3-10,15-18,21H2,1-2H3,(H,37,38,39,40)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information

SMCC is a heterobifunctional protein crosslinker. SMCC is commonly used to prepare antibody-enzyme conjugates. This molecule contains an amine reactive NHS ester on one end, and a maleimide functional group that can be utilized to react specifically with sulfhydryl (-SH) moeities. The maleimide functional group does not readily react with amino group (-NH2) as found on lysine residues, thus maleimide activated conjugates can be readily formed and preserved for later utilization