WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522639
Description: PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. Oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin. Oxytocin receptors are also present in the central nervous system. These receptors modulate a variety of behaviors, including stress and anxiety, social memory and recognition, sexual and aggressive behaviors, bonding (affiliation) and maternal behavior.
MedKoo Cat#: 522639
Chemical Formula: C19H19ClFN5O3
Exact Mass: 419.116
Molecular Weight: 419.8414
Elemental Analysis: C, 54.36; H, 4.56; Cl, 8.44; F, 4.53; N, 16.68; O, 11.43
Synonym: PF-03274167; PF 03274167; PF03274167; PF-3274167; PF 3274167; PF3274167; cligosiban;
IUPAC/Chemical Name: 5-(3-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine
InChi Key: HNIFCPBQMKPRCX-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H19ClFN5O3/c1-27-11-17-23-24-19(26(17)13-4-6-18(28-2)22-8-13)25-9-14(10-25)29-16-5-3-12(21)7-15(16)20/h3-8,14H,9-11H2,1-2H3
SMILES Code: COC1=NC=C(N2C(N3CC(OC4=CC=C(F)C=C4Cl)C3)=NN=C2COC)C=C1
The OXTR protein belongs to the G-protein coupled receptor family, specifically Gq, and acts as a receptor for oxytocin. Its activity is mediated by G proteins that activate several different second messenger systems. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium of the uterus at the end of pregnancy. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are also present in the central nervous system. These receptors modulate a variety of behaviors, including stress and anxiety, social memory and recognition, sexual and aggressive behaviors, bonding (affiliation) and maternal behavior. (https://en.wikipedia.org/wiki/Oxytocin_receptor)