Rabeximod

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319916

CAS#: 872178-65-9

Description: Rabeximod, also known as ROB-803; is an immunomodulator agent. Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders. Rabeximod suppresses arthritis by preventing activation of inflammatory cells, most likely macrophages, in a time dependent fashion, downstream of TLR2 and TLR4 stimulation. Anti-inflammatory treatment of traumatic brain injury with Rabeximod reduces cerebral antigen presentation in mice.

Chemical Structure

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Rabeximod
CAS# 872178-65-9
Instruction

Theoretical Analysis

MedKoo Cat#: 319916
Name: Rabeximod
CAS#: 872178-65-9
Chemical Formula: C22H24ClN5O
Exact Mass: 409.17
Molecular Weight: 409.918
Elemental Analysis: C, 64.46; H, 5.90; Cl, 8.65; N, 17.09; O, 3.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ROB-803; ROB-803; ROB-803; Rabeximod.

IUPAC/Chemical Name: 2-(9-chloro-2,3-dimethyl-6H-indolo[2,3-b]quinoxalin-6-yl)-N-[2-(dimethylamino)ethyl]acetamide

InChi Key: PDNNUMNEXITLCZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24ClN5O/c1-13-9-17-18(10-14(13)2)26-22-21(25-17)16-11-15(23)5-6-19(16)28(22)12-20(29)24-7-8-27(3)4/h5-6,9-11H,7-8,12H2,1-4H3,(H,24,29)

SMILES Code: O=C(NCCN(C)C)CN(C1=NC2=CC(C)=C(C)C=C2N=C13)C4=C3C=C(Cl)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 409.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Israelsson C, Kylberg A, Björklund U, Ebendal T. Anti-inflammatory treatment
of traumatic brain injury with Rabeximod reduces cerebral antigen presentation in
mice. J Neurosci Res. 2015 Oct;93(10):1519-25. doi: 10.1002/jnr.23607. Epub 2015
Jun 10. PubMed PMID: 26068706.


2: Hultqvist M, Nandakumar KS, Björklund U, Holmdahl R. Rabeximod reduces
arthritis severity in mice by decreasing activation of inflammatory cells. Ann
Rheum Dis. 2010 Aug;69(8):1527-32. doi: 10.1136/ard.2009.121178. Epub 2010 Jun
11. PubMed PMID: 20542961.


3: Giusti P, Frascaroli G, Tammik C, Gredmark-Russ S, Söderberg-Nauclér C, Varani
S. The novel anti-rheumatic compound Rabeximod impairs differentiation and
function of human pro-inflammatory dendritic cells and macrophages.
Immunobiology. 2011 Jan-Feb;216(1-2):243-50. doi: 10.1016/j.imbio.2010.04.004.
Epub 2010 Apr 28. PubMed PMID: 20494473.


4: Hultqvist M, Nandakumar KS, Björklund U, Holmdahl R. The novel small molecule
drug Rabeximod is effective in reducing disease severity of mouse models of
autoimmune disorders. Ann Rheum Dis. 2009 Jan;68(1):130-5. doi:
10.1136/ard.2007.085241. Epub 2008 Mar 17. PubMed PMID: 18347009.