WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522636
CAS#: 143984-17-2 (tosylate);
Description: Y-29794 Tosylate is an orally active, potent and specific non-peptide prolyl endopeptidase (PPCE) inhibitor. Y-29794 selectively and competitively inhibited rat brain PPCE (Ki = 0.95 nM) in a reversible manner. Ex vivo study demonstrated that Y-29794 could penetrate into brain to exhibit dose-dependent and long-lasting inhibition. Furthermore, Y-29794 could potentiate the effect of TRH on the release of ACh in the rat hippocampus. Y-29794 prevents the progression of A beta-like deposition in the hippocampus of the SAM.
MedKoo Cat#: 522636
Name: Y-29794 Tosylate
CAS#: 143984-17-2 (tosylate);
Chemical Formula: C30H42N2O4S3
Exact Mass:
Molecular Weight: 590.86
Elemental Analysis: C, 60.98; H, 7.17; N, 4.74; O, 10.83; S, 16.28
Related CAS #: 143984-17-2 (tosylate); 129184-48-1 (free base)
Synonym: Y 29794; Y-29794; Y29794; Y29794 tosylate; Y-29794 tosylate; Y 29794 tosylate.
IUPAC/Chemical Name: (2-((8-(dimethylamino)octyl)thio)-6-isopropylpyridin-3-yl)(thiophen-2-yl)methanone 4-methylbenzenesulfonate
SMILES Code: CC(C1=CC=C(C(C2=CC=CS2)=O)C(SCCCCCCCCN(C)C)=N1)C.CC3=CC=C(S(=O)(O)=O)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 590.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kato A, Fukunari A, Sakai Y, Nakajima T. Prevention of amyloid-like deposition
by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated
mouse. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35. PubMed PMID: 9336340.
2: Nakajima T, Ono Y, Kato A, Maeda J, Ohe T. Y-29794--a non-peptide prolyl
endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992
Jul 20;141(2):156-60. PubMed PMID: 1436628.
Y-29794 free base:
Chemical Formula: C23H34N2OS2
Exact Mass: 418.2113
Molecular Weight: 418.6580
Elemental Analysis: C, 65.99; H, 8.19; N, 6.69; O, 3.82; S, 15.32
