Y-29794 Tosylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522636

CAS#: 143984-17-2 (tosylate);

Description: Y-29794 Tosylate is an orally active, potent and specific non-peptide prolyl endopeptidase (PPCE) inhibitor. Y-29794 selectively and competitively inhibited rat brain PPCE (Ki = 0.95 nM) in a reversible manner. Ex vivo study demonstrated that Y-29794 could penetrate into brain to exhibit dose-dependent and long-lasting inhibition. Furthermore, Y-29794 could potentiate the effect of TRH on the release of ACh in the rat hippocampus. Y-29794 prevents the progression of A beta-like deposition in the hippocampus of the SAM.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 850 Same day
200mg USD 1250 Same day
500mg USD 2650 Same day
1g USD 4650 Same day
2g USD 6150 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-27. Prices are subject to change without notice.

Y29794 tosylate, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 522636
Name: Y-29794 Tosylate
CAS#: 143984-17-2 (tosylate);
Chemical Formula: C30H42N2O4S3
Exact Mass:
Molecular Weight: 590.86
Elemental Analysis: C, 60.98; H, 7.17; N, 4.74; O, 10.83; S, 16.28

Related CAS #: 143984-17-2 (tosylate); 129184-48-1 (free base)  

Synonym: Y 29794; Y-29794; Y29794; Y29794 tosylate; Y-29794 tosylate; Y 29794 tosylate.

IUPAC/Chemical Name: (2-((8-(dimethylamino)octyl)thio)-6-isopropylpyridin-3-yl)(thiophen-2-yl)methanone 4-methylbenzenesulfonate


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Y-29794 free base:
Chemical Formula: C23H34N2OS2
Exact Mass: 418.2113
Molecular Weight: 418.6580
Elemental Analysis: C, 65.99; H, 8.19; N, 6.69; O, 3.82; S, 15.32


1: Kato A, Fukunari A, Sakai Y, Nakajima T. Prevention of amyloid-like deposition
by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated
mouse. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35. PubMed PMID: 9336340.

2: Nakajima T, Ono Y, Kato A, Maeda J, Ohe T. Y-29794--a non-peptide prolyl
endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992
Jul 20;141(2):156-60. PubMed PMID: 1436628.