WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522636
CAS#: 143984-17-2 (tosylate);
Description: Y-29794 Tosylate is an orally active, potent and specific non-peptide prolyl endopeptidase (PPCE) inhibitor. Y-29794 selectively and competitively inhibited rat brain PPCE (Ki = 0.95 nM) in a reversible manner. Ex vivo study demonstrated that Y-29794 could penetrate into brain to exhibit dose-dependent and long-lasting inhibition. Furthermore, Y-29794 could potentiate the effect of TRH on the release of ACh in the rat hippocampus. Y-29794 prevents the progression of A beta-like deposition in the hippocampus of the SAM.
MedKoo Cat#: 522636
Name: Y-29794 Tosylate
CAS#: 143984-17-2 (tosylate);
Chemical Formula: C30H42N2O4S3
Exact Mass:
Molecular Weight: 590.86
Elemental Analysis: C, 60.98; H, 7.17; N, 4.74; O, 10.83; S, 16.28
Related CAS #: 143984-17-2 (tosylate); 129184-48-1 (free base)
Synonym: Y 29794; Y-29794; Y29794; Y29794 tosylate; Y-29794 tosylate; Y 29794 tosylate.
IUPAC/Chemical Name: (2-((8-(dimethylamino)octyl)thio)-6-isopropylpyridin-3-yl)(thiophen-2-yl)methanone 4-methylbenzenesulfonate
SMILES Code: CC(C1=CC=C(C(C2=CC=CS2)=O)C(SCCCCCCCCN(C)C)=N1)C.CC3=CC=C(S(=O)(O)=O)C=C3
Y-29794 free base:
Chemical Formula: C23H34N2OS2
Exact Mass: 418.2113
Molecular Weight: 418.6580
Elemental Analysis: C, 65.99; H, 8.19; N, 6.69; O, 3.82; S, 15.32
1: Kato A, Fukunari A, Sakai Y, Nakajima T. Prevention of amyloid-like deposition
by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated
mouse. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35. PubMed PMID: 9336340.
2: Nakajima T, Ono Y, Kato A, Maeda J, Ohe T. Y-29794--a non-peptide prolyl
endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992
Jul 20;141(2):156-60. PubMed PMID: 1436628.
