WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319875

CAS#: 410528-02-8

Description: Palovarotene, also known as RO-3300074 and R-667, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. Phase I clinical trials of palovarotene in patients with emphysema demonstrated that the drug is well tolerated, with improvements observed in markers of emphysema progression. Emphysema is characterized by the destruction of alveoli and alveolar ducts within the lungs. Retinoid signaling is believed to play a role in alveologenesis, with the retinoic acid receptor gamma thought to be required for alveolar formation.

Price and Availability


USD 250


Palovarotene, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 319875
Name: Palovarotene
CAS#: 410528-02-8
Chemical Formula: C27H30N2O2
Exact Mass: 414.2307
Molecular Weight: 414.549
Elemental Analysis: C, 78.23; H, 7.29; N, 6.76; O, 7.72

Synonym: RO-3300074; RO 3300074; RO3300074; R-667; R 667; R667; Palovarotene

IUPAC/Chemical Name: 4-((1E)-2-(5,5,8,8-Tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl)benzoic acid


InChi Code: InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+

SMILES Code: O=C(O)C1=CC=C(/C=C/C2=C(CN3N=CC=C3)C=C4C(C)(C)CCC(C)(C)C4=C2)C=C1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Stolk J, Stockley RA, Stoel BC, Cooper BG, Piitulainen E, Seersholm N, Chapman
KR, Burdon JG, Decramer M, Abboud RT, Mannes GP, Wouters EF, Garrett JE,
Barros-Tizon JC, Russi EW, Lomas DA, MacNee WA, Rames A. Randomised controlled
trial for emphysema with a selective agonist of the γ-type retinoic acid
receptor. Eur Respir J. 2012 Aug;40(2):306-12. doi: 10.1183/09031936.00161911.
Epub 2012 Jan 26. PubMed PMID: 22282548.

2: Gross NJ. The COPD Pipeline XIII. COPD. 2011 Dec;8(6):464-5. doi:
10.3109/15412555.2011.628597. PubMed PMID: 22149408.

3: Gross NJ. The COPD pipeline VII. COPD. 2010 Dec;7(6):438-40. doi:
10.3109/15412555.2010.527736. PubMed PMID: 21166632.

4: Stolk J, Cooper BG, Stoel B, Rames A, Rutman O, Soliman S, Stockley R.
Retinoid treatment of Emphysema in Patients on the Alpha-1 International
Registry. The REPAIR study: study design, methodology and quality control of
study assessments. Ther Adv Respir Dis. 2010 Dec;4(6):319-32. doi:
10.1177/1753465810379617. Epub 2010 Oct 6. PubMed PMID: 20926506.

5: Hind M, Stinchcombe S. Palovarotene, a novel retinoic acid receptor gamma
agonist for the treatment of emphysema. Curr Opin Investig Drugs. 2009
Nov;10(11):1243-50. Review. PubMed PMID: 19876792.