Umifenovir HCl

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MedKoo CAT#: 319804

CAS#: 131707-23-8 (HCl)

Description: Umifenovir, also known as arbidol, is an antiviral treatment used in Russia and Chinafor influenza infection. Since 2005 it has been the number one best-selling over-the-counter drug in Russia. Umifenovir inhibits membrane fusion. Umifenovir prevents contact between the virus and target host cells. Fusion between the viral capsid and the cell membrane of the target cell is inhibited. This prevents viral entry to the target cell, and therefore protects it from infection.

Price and Availability

Size Price Shipping out time Quantity
50mg USD 90 Same day
1g USD 150 Same day
2g USD 250 Same day
5g USD 450 Same day
20g USD 1250 Same day
50g USD 1850 Same day
100g USD 2950 Same day
200g USD 4650 Same day
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

Umifenovir HCl, purity > 98%, is in stock.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 319804
Name: Umifenovir HCl
CAS#: 131707-23-8 (HCl)
Chemical Formula: C22H26BrClN2O3S
Exact Mass:
Molecular Weight: 513.88
Elemental Analysis: C, 51.42; H, 5.10; Br, 15.55; Cl, 6.90; N, 5.45; O, 9.34; S, 6.24

Related CAS #: 131707-23-8 (HCl)   131707-25-0 (free base)   868364-57-2 (HCl hydrate)    

Synonym: Umifenovir; Umifenovir HCl; Umifenovir hydrochloride; arbidol.

IUPAC/Chemical Name: ethyl 6-bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-indole-3-carboxylate hydrochloride


InChi Code: InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H

SMILES Code: O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C)C)=C(O)C(Br)=C3)OCC.[H]Cl

Technical Data

White to off-white crystalline powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Galiano V, Villalaín J. The Location of the Protonated and Unprotonated Forms of Arbidol in the Membrane: A Molecular Dynamics Study. J Membr Biol. 2016 Feb 3. [Epub ahead of print] PubMed PMID: 26843065.

2: Pécheur EI, Borisevich V, Halfmann P, Morrey JD, Smee DF, Prichard M, Mire CE, Kawaoka Y, Geisbert TW, Polyak SJ. The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses. J Virol. 2016 Jan 6. pii: JVI.02077-15. [Epub ahead of print] PubMed PMID: 26739045.

3: Surov AO, Manin AN, Churakov AV, Perlovich GL. New Solid Forms of the Antiviral Drug Arbidol: Crystal Structures, Thermodynamic Stability, and Solubility. Mol Pharm. 2015 Nov 2;12(11):4154-65. doi: 10.1021/acs.molpharmaceut.5b00629. Epub 2015 Oct 19. PubMed PMID: 26479207.

4: Kiselev OI, Maleev VV, Deeva ÉG, Leneva IA, Sel'kova EP, Osipova EA, Obukhov AA, Nadorov SA, Kulikova EV. [Clinical efficacy of arbidol (umifenovir) in the therapy of influenza in adults: preliminary results of the multicenter double-blind randomized placebo-controlled study ARBITR]. Ter Arkh. 2015;87(1):88-96. Russian. PubMed PMID: 25823275.

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6: Perfetto B, Filosa R, De Gregorio V, Peduto A, La Gatta A, de Caprariis P, Tufano MA, Donnarumma G. In vitro antiviral and immunomodulatory activity of arbidol and structurally related derivatives in herpes simplex virus type 1-infected human keratinocytes (HaCat). J Med Microbiol. 2014 Nov;63(Pt 11):1474-83. doi: 10.1099/jmm.0.076612-0. Epub 2014 Sep 3. PubMed PMID: 25187601.

7: Oestereich L, Rieger T, Neumann M, Bernreuther C, Lehmann M, Krasemann S, Wurr S, Emmerich P, de Lamballerie X, Ölschläger S, Günther S. Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever. PLoS Negl Trop Dis. 2014 May 1;8(5):e2804. doi: 10.1371/journal.pntd.0002804. eCollection 2014 May. PubMed PMID: 24786461; PubMed Central PMCID: PMC4006714.

8: Blaising J, Polyak SJ, Pécheur EI. Arbidol as a broad-spectrum antiviral: an update. Antiviral Res. 2014 Jul;107:84-94. doi: 10.1016/j.antiviral.2014.04.006. Epub 2014 Apr 24. Review. PubMed PMID: 24769245.

9: Liu X, Huang T, Chen JX, Zeng J, Fan XR, Xu-Zhu, Yu ZW, Sun XY, Hong M, Sun HZ. Arbidol exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A9 and 2B7. Pharmazie. 2013 Dec;68(12):945-50. PubMed PMID: 24400440.

10: Leneva IA, Falynskova IN, Leonova EI, Fedyakina IT, Makhmudova NR, Osipova EA, Lepekha LN, Mikhailova NA, Zverev VV. [Umifenovir (Arbidol) efficacy in experimental mixed viral and bacterial pneumonia of mice]. Antibiot Khimioter. 2014;59(9-10):17-24. Russian. PubMed PMID: 25975111.

11: Nasser ZH, Swaminathan K, Müller P, Downard KM. Inhibition of influenza hemagglutinin with the antiviral inhibitor arbidol using a proteomics based approach and mass spectrometry. Antiviral Res. 2013 Nov;100(2):399-406. doi: 10.1016/j.antiviral.2013.08.021. Epub 2013 Sep 4. PubMed PMID: 24012882.

12: Severina IS, Shchegolev AIu, Medvedev AE. [Potentiation of NO-dependent activation of soluble guanylyl cyclase by 5-nitroisatin and antiviral preparatation arbidol]. Biomed Khim. 2013 May-Jun;59(3):295-304. Russian. PubMed PMID: 23987067.

13: Blaising J, Lévy PL, Polyak SJ, Stanifer M, Boulant S, Pécheur EI. Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking. Antiviral Res. 2013 Oct;100(1):215-9. doi: 10.1016/j.antiviral.2013.08.008. Epub 2013 Aug 25. PubMed PMID: 23981392.

14: Liu Q, Xiong HR, Lu L, Liu YY, Luo F, Hou W, Yang ZQ. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013 Aug;34(8):1075-83. doi: 10.1038/aps.2013.54. Epub 2013 Jun 17. PubMed PMID: 23770981; PubMed Central PMCID: PMC4003028.

15: Song JH, Fang ZZ, Zhu LL, Cao YF, Hu CM, Ge GB, Zhao DW. Glucuronidation of the broad-spectrum antiviral drug arbidol by UGT isoforms. J Pharm Pharmacol. 2013 Apr;65(4):521-7. doi: 10.1111/jphp.12014. Epub 2012 Dec 24. PubMed PMID: 23488780.

16: Sun Y, He X, Qiu F, Zhu X, Zhao M, Li-Ling J, Su X, Zhao L. Pharmacokinetics of single and multiple oral doses of arbidol in healthy Chinese volunteers. Int J Clin Pharmacol Ther. 2013 May;51(5):423-32. doi: 10.5414/CP201843. PubMed PMID: 23391367.

17: Liu X, Li H, Bi KS, Chen XH, Cai H, Cai BC. [Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry]. Yao Xue Xue Bao. 2012 Nov;47(11):1521-6. Chinese. PubMed PMID: 23387087.

18: Deng P, Zhong D, Yu K, Zhang Y, Wang T, Chen X. Pharmacokinetics, metabolism, and excretion of the antiviral drug arbidol in humans. Antimicrob Agents Chemother. 2013 Apr;57(4):1743-55. doi: 10.1128/AAC.02282-12. Epub 2013 Jan 28. PubMed PMID: 23357765; PubMed Central PMCID: PMC3623363.

19: Zhang XQ, Dai JP, Cai BQ. [The in-vitro effects of arbidol hydrochloride against 2009 new influenza virus A (H1N1)]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Apr;34(2):126-9. doi: 10.3881/j.issn.1000-503X.2012.02.005. Chinese. PubMed PMID: 22776596.

20: Brooks MJ, Burtseva EI, Ellery PJ, Marsh GA, Lew AM, Slepushkin AN, Crowe SM, Tannock GA. Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions. J Med Virol. 2012 Jan;84(1):170-81. doi: 10.1002/jmv.22234. Epub 2011 Oct 25. PubMed PMID: 22028179.