Forasartan

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317950

CAS#: 145216-43-9

Description: Forasartan is a nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex.

Chemical Structure

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Forasartan
CAS# 145216-43-9
Instruction

Theoretical Analysis

MedKoo Cat#: 317950
Name: Forasartan
CAS#: 145216-43-9
Chemical Formula: C23H28N8
Exact Mass: 416.24
Molecular Weight: 416.520
Elemental Analysis: C, 66.32; H, 6.78; N, 26.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Forasartan; SC-52458; SC 52458; SC52458.

IUPAC/Chemical Name: 5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine

InChi Key: YONOBYIBNBCDSJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30)

SMILES Code: CCCCC1=NN(C(=N1)CCCC)CC2=CN=C(C=C2)C3=CC=CC=C3C4=NNN=N4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 416.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNA
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PubMed PMID: 12593652.


9: Katsuragi T, Sato C, Guangyuan L, Honda K. Inositol(1,4,5)trisphosphate signal
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10: Hagmann M, Nussberger J, Naudin RB, Burns TS, Karim A, Waeber B, Brunner HR.
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11: Bauer JH, Reams GP. The angiotensin II type 1 receptor antagonists. A new
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of calcium-calmodulin pathways in the positive chronotropic response to
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