Tedalinab

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319799

CAS#: 916591-01-0

Description: Tedalinab, also known GRC-10693, isa potent and selective cannabinoid CB2 receptor agonist under development for the treatment of osteoarthritis and neuropathic pain. It has a very high selectivity of 4700x for CB2 over the related CB1 receptor, has good oral bioavailability and has shown promising safety results and effective analgesic and antiinflammatory actions in early clinical trials.


Chemical Structure

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Tedalinab
CAS# 916591-01-0

Theoretical Analysis

MedKoo Cat#: 319799
Name: Tedalinab
CAS#: 916591-01-0
Chemical Formula: C19H21F2N3O
Exact Mass: 345.17
Molecular Weight: 345.394
Elemental Analysis: C, 66.07; H, 6.13; F, 11.00; N, 12.17; O, 4.63

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Synonym: GRC-10693; GRC 10693; GRC10693; Tedalinab

IUPAC/Chemical Name: (4S,7R)-N-(tert-butyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methanoindazole-3-carboxamide

InChi Key: NTPZXHMTJGOMCJ-WDEREUQCSA-N

InChi Code: InChI=1S/C19H21F2N3O/c1-19(2,3)22-18(25)16-15-10-4-5-11(8-10)17(15)24(23-16)14-7-6-12(20)9-13(14)21/h6-7,9-11H,4-5,8H2,1-3H3,(H,22,25)/t10-,11+/m0/s1

SMILES Code: O=C(C1=NN(C2=CC=C(F)C=C2F)C3=C1[C@@]4([H])CC[C@]3([H])C4)NC(C)(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 345.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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