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GNF-7
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407257

CAS#: 839706-07-9

Description: GNF-7 is a type-II T315I inhibitor. GNF-7 inhibits Ack1 and germinal center kinase (GCK). GNF-7 displayed significant in vivo efficacy against T315I-Bcr-Abl without appreciable toxicity in a bioluminescent xenograft mouse model using a transformed T315I-Bcr-Abl-Ba/F3 cell line that has a stable luciferase expression. GNF-7 is among the first type-II inhibitors capable of inhibiting T315I to be described and will serve as a valuable lead to design the third generation Bcr-Abl kinase inhibitors.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 1150 2 Weeks
200mg USD 1850 2 Weeks
500mg USD 2750 2 Weeks
1g USD 3450 2 Weeks
2g USD 5450 2 Weeks
5g USD 7850 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2020-10-28. Prices are subject to change without notice.

GNF-7, purity > 98%, is in stock. Minimum 100mg order. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407257
Name: GNF-7
CAS#: 839706-07-9
Chemical Formula: C28H24F3N7O2
Exact Mass: 547.1944
Molecular Weight: 547.5422
Elemental Analysis: C, 61.42; H, 4.42; F, 10.41; N, 17.91; O, 5.84


Synonym: GNF-7; GNF7; GNF 7.

IUPAC/Chemical Name: N-(4-methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)-3-(trifluoromethyl)benzamide

InChi Key: SZNYUUZOQHNEKB-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36)

SMILES Code: O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Liang X, Liu X, Wang B, Zou F, Wang A, Qi S, Chen C, Zhao Z, Wang W, Qi Z, Lv
F, Hu Z, Wang L, Zhang S, Liu Q, Liu J. Discovery of
2-((3-amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phe
nyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a potent,
selective and orally available BCR-ABL/SRC/p38 kinase inhibitor for Chronic
Myeloid Leukemia. J Med Chem. 2016 Jan 20. [Epub ahead of print] PubMed PMID:
26789553.

2: Lu X, Zhang Z, Ren X, Pan X, Wang D, Zhuang X, Luo J, Yu R, Ding K. Hybrid
pyrimidine alkynyls inhibit the clinically resistance related Bcr-Abl(T315I)
mutant. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3458-63. doi:
10.1016/j.bmcl.2015.07.006. Epub 2015 Jul 9. PubMed PMID: 26195136.

3: Nonami A, Sattler M, Weisberg E, Liu Q, Zhang J, Patricelli MP, Christie AL,
Saur AM, Kohl NE, Kung AL, Yoon H, Sim T, Gray NS, Griffin JD. Identification of
novel therapeutic targets in acute leukemias with NRAS mutations using a
pharmacologic approach. Blood. 2015 May 14;125(20):3133-43. doi:
10.1182/blood-2014-12-615906. Epub 2015 Apr 1. PubMed PMID: 25833960; PubMed
Central PMCID: PMC4432008.

4: Choi HG, Ren P, Adrian F, Sun F, Lee HS, Wang X, Ding Q, Zhang G, Xie Y, Zhang
J, Liu Y, Tuntland T, Warmuth M, Manley PW, Mestan J, Gray NS, Sim T. A type-II
kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.
J Med Chem. 2010 Aug 12;53(15):5439-48. doi: 10.1021/jm901808w. PubMed PMID:
20604564; PubMed Central PMCID: PMC4134510.