WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319650
Description: Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. In vitro and ex vivo research has demonstrated that abametapir not only kills the lice, but also prevents hatching of their eggs. Xeglyze Lotion is emerging as a differentiated development candidate to treat head lice infestations.
MedKoo Cat#: 319650
Chemical Formula: C12H12N2
Exact Mass: 184.1
Molecular Weight: 184.242
Elemental Analysis: C, 78.23; H, 6.57; N, 15.21
Synonym: HA-44; HA44; HA 44; BRN 0123183; BRN-0123183; BRN0123183; Abametapir; Xeglyze; 6,6'-Bi-3-picoline
IUPAC/Chemical Name: 5,5'-dimethyl-2,2'-bipyridinyl
InChi Key: PTRATZCAGVBFIQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3
SMILES Code: CC1=CN=C(C2=NC=C(C)C=C2)C=C1
Appearance: White to off-white solidw powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
|Biological target:||Abametapir is a metalloproteinase (MMP) inhibitor.|
|In vitro activity:||Treatment of head louse eggs with abametapir (0.74% in isopropanol) resulted in complete inhibition of hatching (100% ovicidal) in all stages of egg development from Day 0 to Day 8 (Table 1). At 0.55% abametapir, approximately 5.4% of the 6–8-d-old eggs hatched, in contrast to none of the 0–2- and 3–5-d-old eggs. As the concentration of abametapir declined, egg hatch increased in a concentration-dependent manner. A statistically significant concentration-dependent response was observed for all egg stages, with younger eggs (0–2 d) proving to be the most susceptible (LC50 = 0.108 (0.079–0.13) % abametapir concentration), followed by the 3–5-d-old eggs (LC50 = 0.121 (0.093-0.146) % abametapir concentration), whereas the oldest aged eggs (6–8 d) were most refractory to the treatment (LC50 = 0.160 (0.147–0.174) % abametapir concentration; Fig 1). Reference: J Med Entomol. 2017 Jan; 54(1): 167–172. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853637/|
|In vivo activity:||N/A|
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|Ethanol:PBS (pH 7.2) (1:4)||0.2||1.09|
The following data is based on the product molecular weight 184.242 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
|Formulation protocol:||1. Bowles VM, Yoon KS, Barker SC, Tran C, Rhodes C, Clark MJ. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 Jan;54(1):167-172. doi: 10.1093/jme/tjw132. Epub 2016 Aug 21. Erratum in: J Med Entomol. 2017 Jan 1;54(1):248. PMID: 28082644; PMCID: PMC5853637.|
|In vitro protocol:||N/A|
|In vivo protocol:||1. Bowles VM, Yoon KS, Barker SC, Tran C, Rhodes C, Clark MJ. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 Jan;54(1):167-172. doi: 10.1093/jme/tjw132. Epub 2016 Aug 21. Erratum in: J Med Entomol. 2017 Jan 1;54(1):248. PMID: 28082644; PMCID: PMC5853637.|