Indimilast

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319635

CAS#: 1038825-85-2

Description: Indimilast is a phosphodiesterase IV inhibitor. Phosphodiesterase (PDE) inhibitors modulate lung inflammation and cause bronchodilation by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. PDE-4 inhibitor (PDE4I) is potential useful in chronic obstructive pulmonary disease (COPD).

Chemical Structure

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Indimilast
CAS# 1038825-85-2
Instruction

Theoretical Analysis

MedKoo Cat#: 319635
Name: Indimilast
CAS#: 1038825-85-2
Chemical Formula: C37H40FN7O3S
Exact Mass: 681.29
Molecular Weight: 681.831
Elemental Analysis: C, 65.18; H, 5.91; F, 2.79; N, 14.38; O, 7.04; S, 4.70

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Synonym: Indimilast

IUPAC/Chemical Name: N-{cis-4-[1-(4'-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}[1,1'-biphenyl]-3-yl)-6-fluoro-2,4-dioxo-1,4-dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]cyclohexyl}-2-methyl-1,3-thiazole-4-carboxamide

InChi Key: MKQDRXQEQLCSON-KUKIJGICSA-N

InChi Code: InChI=1S/C37H40FN7O3S/c1-22-18-43(19-23(2)40-22)20-25-7-9-26(10-8-25)27-5-4-6-31(15-27)44-34-32(16-28(38)17-39-34)36(47)45(37(44)48)30-13-11-29(12-14-30)42-35(46)33-21-49-24(3)41-33/h4-10,15-17,21-23,29-30,40H,11-14,18-20H2,1-3H3,(H,42,46)/t22-,23+,29?,30?

SMILES Code: O=C(C1=CSC(C)=N1)NC2CCC(N(C(N(C3=CC(C4=CC=C(CN5C[C@@H](C)N[C@@H](C)C5)C=C4)=CC=C3)C6=NC=C(F)C=C67)=O)C7=O)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 681.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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