AMG-369

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522616

CAS#: 1202073-26-4

Description: AMG-369, also known as KB74649, is a potent dual S1P1/S1P5 agonist with limited activity at S1P3 and no activity at S1P2/S1P4. Dosed orally at 0.1 mg/kg, AMG-369 is shown to reduce blood lymphocyte counts 24 h postdose and delay the onset and reduce the severity of experimental autoimmune encephalomyelitis in rat.


Chemical Structure

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AMG-369
CAS# 1202073-26-4

Theoretical Analysis

MedKoo Cat#: 522616
Name: AMG-369
CAS#: 1202073-26-4
Chemical Formula: C26H22FN3O2S
Exact Mass: 459.1417
Molecular Weight: 459.5394
Elemental Analysis: C, 67.96; H, 4.83; F, 4.13; N, 9.14; O, 6.96; S, 6.98

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Synonym: AMG-369; AMG 369; AMG369; KB-74649; KB74649; KB 74649.

IUPAC/Chemical Name: 1-(3-fluoro-4-(6-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)azetidine-3-carboxylic acid

InChi Key: DSAOIEDPZKHAOM-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H22FN3O2S/c27-21-10-16(13-30-14-17(15-30)25(31)32)6-7-20(21)23-29-22-11-19(12-28-24(22)33-23)26(8-9-26)18-4-2-1-3-5-18/h1-7,10-12,17H,8-9,13-15H2,(H,31,32)

SMILES Code: O=C(C1CN(CC2=CC=C(C3=NC4=CC(C5(C6=CC=CC=C6)CC5)=CN=C4S3)C(F)=C2)C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 459.5394 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Victor J. Cee*†, Mike Frohn†, Brian A. Lanman†, Jennifer Golden†, Kristine Muller†, Susana Neira†, Alex Pickrell†, Heather Arnett‡, Janet Buys†, Anu Gore†, Mike Fiorino†, Michelle Horner†, Andrea Itano†, Matt R. Lee†, Michele McElvain†, Scot Middleton†, Michael Schrag†, Dalia Rivenzon-Segal§, Hugo M. Vargas†, Han Xu†, Yang Xu†, Xuxia Zhang†, Jerry Siu†, Min Wong†, and Roland W. Bürli. Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5. ACS Med. Chem. Lett., 2011, 2 (2), pp 107–112