Encainide Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317771

CAS#: 66794-74-9

Description: Encainide Hydrochloride is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects. One of the anti-arrhythmia, it blocks voltage-gated sodium channels and slows conduction within the His-Purkinje system and myocardium. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.


Chemical Structure

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Encainide Hydrochloride
CAS# 66794-74-9

Theoretical Analysis

MedKoo Cat#: 317771
Name: Encainide Hydrochloride
CAS#: 66794-74-9
Chemical Formula: C22H29ClN2O2
Exact Mass: 0.00
Molecular Weight: 388.930
Elemental Analysis: C 67.94; H, 7.52; Cl, 9.12; N, 7.20; O, 8.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Encainide Hydrochloride; Encainide HCl; Enkaid; 66794-74-9; CHEBI:59880; Encainide, (+)-Isomer; Encainide, (-)-Isomer; Enkaid MJ 9067; MJ-9067;

IUPAC/Chemical Name: 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide;hydrochloride

InChi Key: OJIIZIWOLTYOBS-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H

SMILES Code: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 388.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chase SL, Sloskey GE. Encainide hydrochloride and flecainide acetate: two
class 1c antiarrhythmic agents. Clin Pharm. 1987 Nov;6(11):839-50. Review.
Erratum in: Clin Pharm 1988 Apr;7(4):269. PubMed PMID: 3119276.


2: Treatment of life-threatening ventricular tachycardia with encainide
hydrochloride in patients with left ventricular dysfunction. The
Encainide-Ventricular Tachycardia Study Group. Am J Cardiol. 1988 Sep
15;62(9):571-5. PubMed PMID: 3137797.


3: Myerburg RJ, Kessler KM, Cox MM, Huikuri H, Terracall E, Interian A Jr,
Fernandez P, Castellanos A. Reversal of proarrhythmic effects of flecainide
acetate and encainide hydrochloride by propranolol. Circulation. 1989
Dec;80(6):1571-9. PubMed PMID: 2480856.


4: Horowitz LN. Encainide in lethal ventricular arrhythmias evaluated by
electrophysiologic testing and decrease in symptoms. Am J Cardiol. 1986 Aug
29;58(5):83C-86C. Review. PubMed PMID: 3092624.


5: Morganroth J, Somberg JC, Pool PE, Hsu PH, Lee IK, Durkee J, Salerno DM.
Comparative study of encainide and quinidine in the treatment of ventricular
arrhythmias. J Am Coll Cardiol. 1986 Jan;7(1):9-16. Erratum in: J Am Coll Cardiol
1986 Oct;8(4):992. PubMed PMID: 3079781.


6: Svensson CK, Knowlton PW. Effect of encainide on in vivo drug metabolism in
the rat. Res Commun Chem Pathol Pharmacol. 1987 May;56(2):285-8. PubMed PMID:
3110886.


7: Bartek MJ, Mayol RF, Boarman MP, Gammans RE, Gallo DG. Analysis of encainide
and metabolites in plasma and urine by high-performance liquid chromatography.
Ther Drug Monit. 1988;10(4):446-52. PubMed PMID: 3144068.


8: Anderson JL, Platia EV, Hallstrom A, Henthorn RW, Buckingham TA, Carlson MD,
Carson PE. Interaction of baseline characteristics with the hazard of encainide,
flecainide, and moricizine therapy in patients with myocardial infarction. A
possible explanation for increased mortality in the Cardiac Arrhythmia
Suppression Trial (CAST). Circulation. 1994 Dec;90(6):2843-52. PubMed PMID:
7994829.


9: Case CL, Hewett KW, Gillette PC. Developmental electrophysiology of encainide
and its major metabolites on the Purkinje fiber action potential. Biol Neonate.
1994;66(6):330-8. PubMed PMID: 7727615.


10: Wallace AA, Stupienski RF 3rd, Kothstein T, Gehret JR, Lynch JJ Jr.
Demonstration of proarrhythmic activity with the class IC antiarrhythmic agent
encainide in a canine model of previous myocardial infarction. J Cardiovasc
Pharmacol. 1993 Mar;21(3):397-404. PubMed PMID: 7681500.


11: Funck-Brentano C, Thomas G, Jacqz-Aigrain E, Poirier JM, Simon T, Béréziat G,
Jaillon P. Polymorphism of dextromethorphan metabolism: relationships between
phenotype, genotype and response to the administration of encainide in humans. J
Pharmacol Exp Ther. 1992 Nov;263(2):780-6. PubMed PMID: 1432700.


12: Winter WE, Funahashi M, Koons J. Encainide-induced diabetes: analysis of
islet cell function. Res Commun Chem Pathol Pharmacol. 1992 Jun;76(3):259-68.
PubMed PMID: 1636050.


13: Buchanan LV, Kabell G, Turcotte UM, Brunden MN, Gibson JK. Effects of
ibutilide on spontaneous and induced ventricular arrhythmias in 24-hour canine
myocardial infarction: a comparative study with sotalol and encainide. J
Cardiovasc Pharmacol. 1992 Feb;19(2):256-63. PubMed PMID: 1376795.


14: Hilleman DE, Mohiuddin SM, Destache CJ, Stoysich AM, Nipper HC, Malesker MA.
Impact of food on the bioavailability of encainide. J Clin Pharmacol. 1992
Sep;32(9):833-7. PubMed PMID: 1430302.


15: Akiyama T, Pawitan Y, Greenberg H, Kuo CS, Reynolds-Haertle RA. Increased
risk of death and cardiac arrest from encainide and flecainide in patients after
non-Q-wave acute myocardial infarction in the Cardiac Arrhythmia Suppression
Trial. CAST Investigators. Am J Cardiol. 1991 Dec 15;68(17):1551-5. PubMed PMID:
1720917.


16: Lee JH, Rosen MR. Use-dependent actions and effects on transmembrane action
potentials of flecainide, encainide, and ethmozine in canine Purkinje fibers. J
Cardiovasc Pharmacol. 1991 Aug;18(2):285-92. PubMed PMID: 1717791.


17: Roden DM, Lee JT, Woosley RL, Echt DS. Antiarrhythmic efficacy, clinical
electrophysiology, and pharmacokinetics of 3-methoxy-O-desmethyl encainide (MODE)
in patients with inducible ventricular tachycardia or fibrillation. Circulation.
1989 Nov;80(5):1247-58. PubMed PMID: 2805262.


18: Dawson AK, Roden DM, Duff HJ, Woosley RL, Smith RF. Differential effects of
O-demethyl encainide on induced and spontaneous arrhythmias in the conscious dog.
Am J Cardiol. 1984 Sep 1;54(6):654-8. PubMed PMID: 6475789.


19: Duff HJ, Dawson AK, Roden DM, Oates JA, Smith RF, Woosley RL.
Electrophysiologic actions of O-demethyl encainide: an active metabolite.
Circulation. 1983 Aug;68(2):385-91. PubMed PMID: 6861313.


20: Ware DL, Lee JT, Murray KT, Hanyok JJ, Roden DM, Echt DS. Intravenous
3-methoxy-O-desmethyl-encainide in reentrant supraventricular tachycardia: a
randomized double-blind placebo-controlled trial in patients undergoing EP study.
Pacing Clin Electrophysiol. 1991 Sep;14(9):1343-50. PubMed PMID: 1720527.