ICA-121431
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522583

CAS#: 313254-51-2

Description: ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels. Voltage-gated sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy.


Chemical Structure

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ICA-121431
CAS# 313254-51-2

Theoretical Analysis

MedKoo Cat#: 522583
Name: ICA-121431
CAS#: 313254-51-2
Chemical Formula: C23H19N3O3S2
Exact Mass: 449.0868
Molecular Weight: 449.543
Elemental Analysis: C, 61.45; H, 4.26; N, 9.35; O, 10.68; S, 14.26

Price and Availability

Size Price Availability Quantity
5.0mg USD 240.0 2 Weeks
25.0mg USD 600.0 2 Weeks
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Synonym: ICA-121431; ICA 121431; ICA121431.

IUPAC/Chemical Name: 2,2-diphenyl-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)acetamide

InChi Key: URSQNPPONHUJDL-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H19N3O3S2/c27-22(21(17-7-3-1-4-8-17)18-9-5-2-6-10-18)25-19-11-13-20(14-12-19)31(28,29)26-23-24-15-16-30-23/h1-16,21H,(H,24,26)(H,25,27)

SMILES Code: O=C(NC1=CC=C(S(=O)(NC2=NC=CS2)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 449.543 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: McCormack K, Santos S, Chapman ML, Krafte DS, Marron BE, West CW, Krambis MJ,
Antonio BM, Zellmer SG, Printzenhoff D, Padilla KM, Lin Z, Wagoner PK, Swain NA,
Stupple PA, de Groot M, Butt RP, Castle NA. Voltage sensor interaction site for
selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl
Acad Sci U S A. 2013 Jul 16;110(29):E2724-32. doi: 10.1073/pnas.1220844110. Epub
2013 Jul 1. PubMed PMID: 23818614; PubMed Central PMCID: PMC3718154.