JZP-430
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MedKoo CAT#: 522579

CAS#: 1672691-74-5

Description: JZP-430 is a potent and selective ABHD6 inhibitor. P-430 potently and irreversibly inhibited hABHD6 (IC50 =44 nM) and showed ∼230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds. Additionally, activity-based protein profiling indicated that JZP-430 displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. JZP-430 has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes.


Chemical Structure

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JZP-430
CAS# 1672691-74-5

Theoretical Analysis

MedKoo Cat#: 522579
Name: JZP-430
CAS#: 1672691-74-5
Chemical Formula: C16H26N4O3S
Exact Mass: 354.17
Molecular Weight: 354.469
Elemental Analysis: C, 54.22; H, 7.39; N, 15.81; O, 13.54; S, 9.04

Price and Availability

Size Price Availability Quantity
5mg USD 300 2 Weeks
10mg USD 550 2 Weeks
25mg USD 950 2 Weeks
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Synonym: JZP-430; JZP 430; JZP430.

IUPAC/Chemical Name: 4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate

InChi Key: WKSHMJCYWFOADB-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H26N4O3S/c1-19(13-7-5-3-2-4-6-8-13)16(21)23-15-14(17-24-18-15)20-9-11-22-12-10-20/h13H,2-12H2,1H3

SMILES Code: O=C(OC1=NSN=C1N2CCOCC2)N(C3CCCCCCC3)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 354.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Patel JZ, Nevalainen TJ, Savinainen JR, Adams Y, Laitinen T, Runyon RS, Vaara
M, Ahenkorah S, Kaczor AA, Navia-Paldanius D, Gynther M, Aaltonen N, Joharapurkar
AA, Jain MR, Haka AS, Maxfield FR, Laitinen JT, Parkkari T. Optimization of
1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.
ChemMedChem. 2015 Feb;10(2):253-65. doi: 10.1002/cmdc.201402453. Epub 2014 Dec
11. PubMed PMID: 25504894; PubMed Central PMCID: PMC4471478.