WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407243

CAS#: 725233-55-6

Description: ISS610 is a STAT3 inhibitor. Aberrant activation of oncogenic signal transducer and activator of transcription 3 (STAT3) protein signaling pathways has been extensively implicated in human cancers.

Chemical Structure

CAS# 725233-55-6

Theoretical Analysis

MedKoo Cat#: 407243
Name: ISS610
CAS#: 725233-55-6
Chemical Formula: C23H26N3O8P
Exact Mass: 503.1458
Molecular Weight: 503.4478
Elemental Analysis: C, 54.87; H, 5.21; N, 8.35; O, 25.42; P, 6.15

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Synonym: ISS610; ISS-610; ISS 610.

IUPAC/Chemical Name: ((S)-2-(4-cyanobenzamido)-3-(4-(phosphonooxy)phenyl)propanoyl)-L-leucine


InChi Code: InChI=1S/C23H26N3O8P/c1-14(2)11-20(23(29)30)26-22(28)19(25-21(27)17-7-3-16(13-24)4-8-17)12-15-5-9-18(10-6-15)34-35(31,32)33/h3-10,14,19-20H,11-12H2,1-2H3,(H,25,27)(H,26,28)(H,29,30)(H2,31,32,33)/t19-,20-/m0/s1

SMILES Code: CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C2=CC=C(C#N)C=C2)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 503.4478 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shahani VM, Yue P, Fletcher S, Sharmeen S, Sukhai MA, Luu DP, Zhang X, Sun H, Zhao W, Schimmer AD, Turkson J, Gunning PT. Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein. Bioorg Med Chem. 2011 Mar 1;19(5):1823-38. doi: 10.1016/j.bmc.2010.12.010. Epub 2010 Dec 9. PubMed PMID: 21216604; PubMed Central PMCID: PMC3151534.


10.0mg / Not available