FK-3311 | CAS#116686-15-8 | cyclooxygenase-2 (COX-2) inhibitor

FK3311
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522573

CAS#: 116686-15-8

Description: FK3311 is a cyclooxygenase-2 (COX-2) inhibitor. FK3311 has protective effects on hepatic ischemia-reperfusion injury stemming from the marked inhibition of TxA2. Ischemia-reperfusion injury is induced by activation of the arachidonic acid cascade following the induction of cyclooxygenase-2.

Chemical Structure

FK3311

CAS# 116686-15-8

Instruction

Theoretical Analysis

MedKoo Cat#: 522573
Name: FK3311
CAS#: 116686-15-8
Chemical Formula: C15H13F2NO4S
Exact Mass: 341.05
Molecular Weight: 341.329
Elemental Analysis: C, 52.78; H, 3.84; F, 11.13; N, 4.10; O, 18.75; S, 9.39

Price and Availability

Size	Price	Availability
100mg	USD 950	2 Weeks
200mg	USD 1650	2 Weeks
500mg	USD 2450	2 Weeks
1g	USD 3450	2 Weeks
2g	USD 5650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: FK-3311; FK 3311; FK3311.

IUPAC/Chemical Name: N-(4-acetyl-2-(2,4-difluorophenoxy)phenyl)methanesulfonamide

InChi Key: DIIYLGZNZGPXRR-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3

SMILES Code: CS(=O)(NC1=CC=C(C(C)=O)C=C1OC2=CC=C(F)C=C2F)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 341.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Oshima K, Yabata Y, Yoshinari D, Takeyoshi I. The effects of cyclooxygenase (COX)-2 inhibition on ischemia-reperfusion injury in liver transplantation. J Invest Surg. 2009 Jul-Aug;22(4):239-45. PubMed PMID: 19842898.

2: Otani Y, Takeyoshi I, Yoshinari D, Matsumoto K, Morishita Y. Effects of the COX-2 inhibitor FK3311 on ischemia - reperfusion injury in the rat lung. J Invest Surg. 2007 May-Jun;20(3):175-80. PubMed PMID: 17613692.

3: Kobayashi M, Takeyoshi I, Kurabayashi M, Matsumoto K, Morishita Y. The effects of a cyclooxygenase-2 inhibitor, FK3311, on total hepatic ischemia-reperfusion injury of the rat. Hepatogastroenterology. 2007 Mar;54(74):522-6. PubMed PMID: 17523312.

4: Oshima K, Takeyoshi I, Tsutsumi H, Mohara J, Ohki S, Koike N, Nameki T, Matsumoto K, Morishita Y. Inhibition of cyclooxygenase-2 improves cardiac function following long-term preservation. J Surg Res. 2006 Oct;135(2):380-4. Epub 2006 May 19. PubMed PMID: 16713604.

5: Kawata K, Takeyoshi I, Iwanami K, Sunose Y, Tsutsumi H, Ohwada S, Matsumoto K, Morishita Y. The effects of a selective cyclooxygenase-2 inhibitor on small bowel ischemia-reperfusion injury. Hepatogastroenterology. 2003 Nov-Dec;50(54):1970-4. PubMed PMID: 14696445.

6: Sunose Y, Takeyoshi I, Tsutsumi H, Ohwada S, Oriuchi N, Matsumoto K, Morishita Y. Effect of a cyclooxygenase-2 inhibitor, FK3311, in a canine lung transplantation model. Ann Thorac Surg. 2001 Oct;72(4):1165-71; discussion 1171-2. PubMed PMID: 11603431.

7: Takeyoshi I, Sunose Y, Iwazaki S, Tsutsumi H, Aiba M, Kasahara M, Ohwada S, Matsumoto K, Morishita Y. The effect of a selective cyclooxygenase-2 inhibitor in extended liver resection with ischemia in dogs. J Surg Res. 2001 Sep;100(1):25-31. PubMed PMID: 11516201.

8: Sunose Y, Takeyoshi I, Ohwada S, Tsutsumi H, Iwazaki S, Kawata K, Kawashima Y, Kasahara M, Matsumoto K, Morishita Y. Selective cyclooxygenase-2 inhibitor ameliorates warm ischemia-reperfusion injury of the canine liver. Transplant Proc. 2001 Feb-Mar;33(1-2):862. PubMed PMID: 11267104.

9: Sunose Y, Takeyoshi I, Ohwada S, Tsutsumi H, Iwazaki S, Kawata K, Kawashima Y, Tomizawa N, Matsumoto K, Morishita Y. The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model. J Am Coll Surg. 2001 Jan;192(1):54-62. PubMed PMID: 11192923.

10: Sunose Y, Takeyoshi I, Tsutsumi H, Kawata K, Tokumine M, Iwazaki S, Tomizawa N, Ohwada S, Matsumoto K, Morishita Y. Effects of FK3311 on pulmonary ischemia-reperfusion injury in a canine model. J Surg Res. 2001 Feb;95(2):167-73. PubMed PMID: 11162041.

11: Kasahara M, Takeyoshi I, Ohwada S, Sunose Y, Iwazaki S, Aiba M, Tomizawa N, Tsutsumi H, Kawashima Y, Ogawa T, Kawate S, Matsumoto K, Morishita Y. Effect of FK3311 on ischemia-reperfusion injury in canine pulmonary models. Transplant Proc. 2000 Nov;32(7):2430-1. PubMed PMID: 11120230.

12: Takeyoshi I, Sunose Y, Iwazaki S, Tsutsumi H, Aiba M, Tomizawa N, Kawashima Y, Kasahara M, Kawate S, Ogawa T, Ohwada S, Matsumoto K, Morishita Y. The effect of cyclooxygenase 2 inhibitor (FK3311) on ischemia-reperfusion injury with hepatectomy in dogs. Transplant Proc. 2000 Nov;32(7):2322-3. PubMed PMID: 11120183.

13: Tsuji K, Nakamura K, Konishi N, Tojo T, Ochi T, Senoh H, Matsuo M. Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives. Chem Pharm Bull (Tokyo). 1997 Jun;45(6):987-95. PubMed PMID: 9214705.

14: Nakamura K, Ochi T, Matsuo M. [Stereoselective synthesis and pharmacological properties of metabolites of new antiinflammatory agent. 4'-Acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311)]. Yakugaku Zasshi. 1995 Nov;115(11):928-36. Japanese. PubMed PMID: 8568636.

15: Nakamura K, Tsuji K, Konishi N, Matsuo M. Studies on antiinflammatory agents. III. Synthesis and pharmacological properties of metabolites of 4'-acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311). Chem Pharm Bull (Tokyo). 1993 Nov;41(11):2050-2. PubMed PMID: 8293528.

Your view history

FK3311 featured