ORY1001 HCl
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MedKoo CAT#: 558251

CAS#: 1431303-72-8 (2HCl)

Description: ORY1001, also known as RG-6016, is KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). ORY-1001 does not inhibit non-related histone modifiers. Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers (EC50 me2H3K4 and FACS CD11b <1nM). ORY-1001 induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells (EC50 <1nM).


Chemical Structure

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ORY1001 HCl
CAS# 1431303-72-8 (2HCl)

Theoretical Analysis

MedKoo Cat#: 558251
Name: ORY1001 HCl
CAS#: 1431303-72-8 (2HCl)
Chemical Formula: C15H24Cl2N2
Exact Mass: 230.1783
Molecular Weight: 303.271
Elemental Analysis: C, 59.41; H, 7.98; Cl, 23.38; N, 9.24

Price and Availability

Size Price Availability Quantity
50.0mg USD 350.0 2 Weeks
100.0mg USD 550.0 2 Weeks
200.0mg USD 950.0 2 Weeks
500.0mg USD 2150.0 2 Weeks
1.0g USD 3850.0 2 Weeks
2.0g USD 6650.0 2 Weeks
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Related CAS #: 1431303-72-8 (2HCl)   1431304-21-0 (free base)   1431303-71-7 (xHCl)   1431326-61-2 (2HCl)  

Synonym: ORY1001; ORY-1001; ORY1001; RG6016; RG 6016; RG-6016; ORY1001 dihydrochloride, ORY1001 HCl; ORY1001 2HCl salt.

IUPAC/Chemical Name: (1r,4R)-N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride

InChi Key: UCINOBZMLCREGM-ISDLZHGDSA-N

InChi Code: InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12-,13-,14-,15+;;/m0../s1

SMILES Code: N[C@@H]1CC[C@@H](N[C@@H]2C[C@H]2C3=CC=CC=C3)CC1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 303.271 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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