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BQCA
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522555

CAS#: 338747-41-4

Description: BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5. Stimulation of the cortical muscarinic M1 receptor (CHRM1) is proposed as a treatment for schizophrenia, a hypothesis testable using CHRM1 allosteric modulators. BQCA binds allosterically to M1 to enhance the binding and efficacy of ACh at the receptor. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2850 2 Weeks
2g USD 4250 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2020-10-31. Prices are subject to change without notice.

BQCA , purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522555
Name: BQCA
CAS#: 338747-41-4
Chemical Formula: C18H15NO4
Exact Mass: 309.1001
Molecular Weight: 309.321
Elemental Analysis: C, 69.89; H, 4.89; N, 4.53; O, 20.69


Synonym: BQCA, CAS#338747-41-4.

IUPAC/Chemical Name: 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

InChi Key: BZBBTGCKPRSPGF-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H15NO4/c1-23-13-8-6-12(7-9-13)10-19-11-15(18(21)22)17(20)14-4-2-3-5-16(14)19/h2-9,11H,10H2,1H3,(H,21,22)

SMILES Code: O=C(C1=CN(CC2=CC=C(OC)C=C2)C3=C(C=CC=C3)C1=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Dean B, Hopper S, Conn PJ, Scarr E. Changes in BQCA Allosteric Modulation of
[(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations.
Neuropsychopharmacology. 2015 Oct 29. doi: 10.1038/npp.2015.330. [Epub ahead of
print] PubMed PMID: 26511338.

2: Davie BJ, Valant C, White JM, Sexton PM, Capuano B, Christopoulos A, Scammells
PJ. Synthesis and pharmacological evaluation of analogues of benzyl quinolone
carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the
M ₁ muscarinic acetylcholine receptor. J Med Chem. 2014 Jun 26;57(12):5405-18.
doi: 10.1021/jm500556a. Epub 2014 Jun 5. PubMed PMID: 24856614.

3: Mistry SN, Valant C, Sexton PM, Capuano B, Christopoulos A, Scammells PJ.
Synthesis and pharmacological profiling of analogues of benzyl quinolone
carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. J
Med Chem. 2013 Jun 27;56(12):5151-72. doi: 10.1021/jm400540b. Epub 2013 Jun 17.
PubMed PMID: 23718562.