WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407236

CAS#: 691392-89-9

Description: MS-0022 is a SMO antagonist. MS-0022 showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low µM range. MS-0022 reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. MS-0022 is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo.

Chemical Structure

CAS# 691392-89-9

Theoretical Analysis

MedKoo Cat#: 407236
Name: MS-0022
CAS#: 691392-89-9
Chemical Formula: C21H16BrN3O
Exact Mass: 405.0477
Molecular Weight: 406.28
Elemental Analysis: C, 62.08; H, 3.97; Br, 19.67; N, 10.34; O, 3.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MS-0022; MS 0022; MS0022.

IUPAC/Chemical Name: 2-bromo-N-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide


InChi Code: InChI=1S/C21H16BrN3O/c1-14-5-4-12-25-13-19(24-20(14)25)15-8-10-16(11-9-15)23-21(26)17-6-2-3-7-18(17)22/h2-13H,1H3,(H,23,26)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 406.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Roberg-Larsen H, Strand MF, Grimsmo A, Olsen PA, Dembinski JL, Rise F,
Lundanes E, Greibrokk T, Krauss S, Wilson SR. High sensitivity measurements of
active oxysterols with automated filtration/filter backflush-solid phase
extraction-liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Sep
14;1255:291-7. doi: 10.1016/j.chroma.2012.02.002. Epub 2012 Feb 28. PubMed PMID:

2: Strand MF, Wilson SR, Dembinski JL, Holsworth DD, Khvat A, Okun I, Petersen D,
Krauss S. A novel synthetic smoothened antagonist transiently inhibits pancreatic
adenocarcinoma xenografts in a mouse model. PLoS One. 2011;6(6):e19904. doi:
10.1371/journal.pone.0019904. Epub 2011 Jun 15. PubMed PMID: 21698280; PubMed
Central PMCID: PMC3115942.