WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522552
CAS#: 1356497-92-1
Description: PT-S58 is a PPAR β/δ full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are effective on PPRE-independent functions of PPARβ/δ. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT.
MedKoo Cat#: 522552
Name: PT-S58
CAS#: 1356497-92-1
Chemical Formula: C17H22N2O5S2
Exact Mass: 398.097
Molecular Weight: 398.492
Elemental Analysis: C, 51.24; H, 5.56; N, 7.03; O, 20.07; S, 16.09
This product is not in stock, which may be available by custom synthesis.
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Synonym: PT-S58; PT-S-58; PT-S 58.
IUPAC/Chemical Name: methyl 3-(N-(4-(tert-butylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate
InChi Key: JSUWAIOZKBYWCJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H22N2O5S2/c1-17(2,3)18-11-6-7-12(13(10-11)23-4)19-26(21,22)14-8-9-25-15(14)16(20)24-5/h6-10,18-19H,1-5H3
SMILES Code: O=C(C1=C(S(=O)(NC2=CC=C(NC(C)(C)C)C=C2OC)=O)C=CS1)OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 398.492 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Naruhn S, Toth PM, Adhikary T, Kaddatz K, Pape V, Dörr S, Klebe G,
Müller-Brüsselbach S, Diederich WE, Müller R. High-affinity peroxisome
proliferator-activated receptor β/δ-specific ligands with pure antagonistic or
inverse agonistic properties. Mol Pharmacol. 2011 Nov;80(5):828-38. doi:
10.1124/mol.111.074039. Epub 2011 Aug 23. PubMed PMID: 21862691.
