Olumacostat glasaretil
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MedKoo CAT#: 319586

CAS#: 1261491-89-7

Description: Olumacostat glasaretil or OG is an acetyl-CoA carboxylase inhibitor. OG inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. OG is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic acid (TOFA) and was designed to enhance delivery in vivo. Topical application of OG but not TOFA significantly reduced hamster ear sebaceous gland size indicating that this pro-drug approach was critical to obtain the desired activity in vivo.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same Day
25mg USD 250 Same Day
50mg USD 450 Same Day
100mg USD 650 Same Day
200mg USD 1050 Same Day
500mg USD 1950 Same Day
1g USD 2450 Same Day
2g USD 3850 Same Day
5g USD 5950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-20. Prices are subject to change without notice.

Olumacostat glasaretil purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319586
Name: Olumacostat glasaretil
CAS#: 1261491-89-7
Chemical Formula: C26H43NO7
Exact Mass: 481.304
Molecular Weight: 481.63
Elemental Analysis: C, 64.84; H, 9.00; N, 2.91; O, 23.25


Synonym: Olumacostat glasaretil; DRM01B; DRM-01B; DRM 01B.

IUPAC/Chemical Name: 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-(tetradecyloxy)furan-2-carboxylate

InChi Key: FYJLDICZGDFWKP-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H43NO7/c1-4-6-7-8-9-10-11-12-13-14-15-16-19-32-25-18-17-22(34-25)26(30)33-21-23(28)27(3)20-24(29)31-5-2/h17-18H,4-16,19-21H2,1-3H3

SMILES Code: O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)OCC(N(CC(OCC)=O)C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Inhibition of ACC activity in the sebaceous glands is designed to substantially impact sebum production since over 80% of human sebum components contain fatty acids. OG inhibits de novo lipid synthesis in primary and transformed human sebocytes.


References

1: Bissonnette R, Poulin Y, Drew J, Hofland H, Tan J. Olumacostat glasaretil, a
novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa,
multicenter, randomized, vehicle-controlled study. J Am Acad Dermatol. 2017
Jan;76(1):33-39. doi: 10.1016/j.jaad.2016.08.053. Epub 2016 Oct 28. PubMed PMID:
28029390.

2: Hunt DW, Winters GC, Brownsey RW, Kulpa JE, Gilliland KL, Thiboutot DM,
Hofland HE. Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase
Inhibitor Olumacostat Glasaretil. J Invest Dermatol. 2017 Mar 1. pii:
S0022-202X(17)30186-0. doi: 10.1016/j.jid.2016.12.031. [Epub ahead of print]
PubMed PMID: 28259683.