NQDI-1
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MedKoo CAT#: 522544

CAS#: 175026-96-7

Description: NQDI-1 is an inhibitor of ASK1, which attenuates acute ischemic renal injury by modulating oxidative stress and cell death. NQDI-1 was used to study LPS-induced activation and role of ASK1 and p38 in anti-inflammatory cytokine production by macrophages Apoptosis signal-regulating kinase 1 (ASK1) is among the signaling events that lead to postischemic cell death. Inhibition of ASK1 pathway protected hearts from ischemic damage.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2850 2 Weeks
2g USD 3950 2 Weeks
5g USD 5650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-26. Prices are subject to change without notice.

NQDI-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522544
Name: NQDI-1
CAS#: 175026-96-7
Chemical Formula: C19H13NO4
Exact Mass: 319.0845
Molecular Weight: 319.31
Elemental Analysis: C, 71.47; H, 4.10; N, 4.39; O, 20.04


Synonym: NQDI1; NQDI-1; NQDI 1. CAS#175026-96-7

IUPAC/Chemical Name: ethyl 2,7-dioxo-2,7-dihydro-3H-naphtho[1,2,3-de]quinoline-1-carboxylate

InChi Key: UFJGFNHRMPMALC-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)

SMILES Code: O=C(C1=C2C3=C(NC1=O)C=CC=C3C(C4=C2C=CC=C4)=O)OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Eaton GJ, Zhang QS, Diallo C, Matsuzawa A, Ichijo H, Steinbeck MJ, Freeman TA.
Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone
formation by increasing chondrocyte survival. Cell Death Dis. 2014 Nov
13;5:e1522. doi: 10.1038/cddis.2014.480. PubMed PMID: 25393478; PubMed Central
PMCID: PMC4260738.

2: Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y,
Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem
cells to reveal pathogenic gene mutations and explore treatments for retinitis
pigmentosa. Mol Brain. 2014 Jun 16;7:45. doi: 10.1186/1756-6606-7-45. PubMed
PMID: 24935155; PubMed Central PMCID: PMC4058693.

3: El Eter E. NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury
by modulating oxidative stress and cell death. Cardiovasc Hematol Agents Med
Chem. 2013 Sep;11(3):179-86. PubMed PMID: 23952292.

4: Nomura K, Lee M, Banks C, Lee G, Morris BJ. An ASK1-p38 signalling pathway
mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells. Neurosci
Lett. 2013 Aug 9;549:163-7. doi: 10.1016/j.neulet.2013.05.045. Epub 2013 Jun 4.
PubMed PMID: 23742763.

5: Volynets GP, Chekanov MO, Synyugin AR, Golub AG, Kukharenko OP, Bdzhola VG,
Yarmoluk SM. Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as
inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J Med Chem. 2011 Apr
28;54(8):2680-6. doi: 10.1021/jm200117h. Epub 2011 Mar 30. PubMed PMID: 21449566.