Acebilustat
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MedKoo CAT#: 319573

CAS#: 943764-99-6

Description: Acebilustat, also known as ZK322, is a potent and selective leukotriene A4 hydrolase inhibitor.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 350 2 Weeks
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3250 2 Weeks
2g USD 4950 2 Weeks
5g USD 11450 2 Weeks
10g USD 18750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-28. Prices are subject to change without notice.

Acebilustat, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319573
Name: Acebilustat
CAS#: 943764-99-6
Chemical Formula: C29H27N3O4
Exact Mass: 481.2002
Molecular Weight: 481.55
Elemental Analysis: C, 72.33; H, 5.65; N, 8.73; O, 13.29


Synonym: ZK322; ZK-322; ZK 322; CTX-4430; EP-501; CTX4430; EP501; CTX 4430; EP 501; Acebilustat, CAS#943764-99-6

IUPAC/Chemical Name: 4-(((1S,4S)-5-(4-(4-(oxazol-2-yl)phenoxy)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)benzoic acid

InChi Key: GERJIEKMNDGSCS-DQEYMECFSA-N

InChi Code: InChI=1S/C29H27N3O4/c33-29(34)23-5-1-20(2-6-23)16-31-18-25-15-24(31)19-32(25)17-21-3-9-26(10-4-21)36-27-11-7-22(8-12-27)28-30-13-14-35-28/h1-14,24-25H,15-19H2,(H,33,34)/t24-,25-/m0/s1

SMILES Code: O=C(O)C1=CC=C(CN2[C@](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[C@]3([H])C2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Elborn JS, Horsley A, MacGregor G, Bilton D, Grosswald R, Ahuja S, Springman
EB. Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients
with Cystic Fibrosis. Clin Transl Sci. 2017 Jan;10(1):28-34. doi:
10.1111/cts.12428. PubMed PMID: 27806191.

2: Elborn JS, Bhatt L, Grosswald R, Ahuja S, Springman EB. Phase I Studies of
Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A
Induction. Clin Transl Sci. 2017 Jan;10(1):20-27. doi: 10.1111/cts.12426. PubMed
PMID: 27792868.