AF3442

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522541

CAS#: 924636-93-1

Description: AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional relevance of this observation deserves to be investigated in vivo.

Chemical Structure

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AF3442
CAS# 924636-93-1
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 522541
Name: AF3442
CAS#: 924636-93-1
Chemical Formula: C22H17F3N2O
Exact Mass: 382.1293
Molecular Weight: 382.39
Elemental Analysis: C, 69.10; H, 4.48; F, 14.91; N, 7.33; O, 4.18

Size Price Shipping out time Quantity
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Pricing updated 2021-03-04. Prices are subject to change without notice.

AF3442, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: AF3442; AF-3442; AF 3442.

IUPAC/Chemical Name: N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl) benzamide

InChi Key: GHLDHBQXNPNZEI-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H17F3N2O/c1-2-27-19-10-6-4-7-15(19)17-13-14(11-12-20(17)27)26-21(28)16-8-3-5-9-18(16)22(23,24)25/h3-13H,2H2,1H3,(H,26,28)

SMILES Code: O=C(NC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3)C4=CC=CC=C4C(F)(F)F

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 382.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bruno A, Di Francesco L, Coletta I, Mangano G, Alisi MA, Polenzani L, Milanese
C, Anzellotti P, Ricciotti E, Dovizio M, Di Francesco A, Tacconelli S, Capone ML,
Patrignani P. Effects of AF3442
[N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of
human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human
monocytes in vitro. Biochem Pharmacol. 2010 Apr 1;79(7):974-81. doi:
10.1016/j.bcp.2009.11.011. Epub 2009 Nov 27. PubMed PMID: 19925781.

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AF3442

1g / Ask price