WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522541
Description: AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional relevance of this observation deserves to be investigated in vivo.
MedKoo Cat#: 522541
Chemical Formula: C22H17F3N2O
Exact Mass: 382.1293
Molecular Weight: 382.39
Elemental Analysis: C, 69.10; H, 4.48; F, 14.91; N, 7.33; O, 4.18
AF3442, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: AF3442; AF-3442; AF 3442.
IUPAC/Chemical Name: N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl) benzamide
InChi Key: GHLDHBQXNPNZEI-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H17F3N2O/c1-2-27-19-10-6-4-7-15(19)17-13-14(11-12-20(17)27)26-21(28)16-8-3-5-9-18(16)22(23,24)25/h3-13H,2H2,1H3,(H,26,28)
SMILES Code: O=C(NC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3)C4=CC=CC=C4C(F)(F)F
The following data is based on the product molecular weight 382.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Bruno A, Di Francesco L, Coletta I, Mangano G, Alisi MA, Polenzani L, Milanese
C, Anzellotti P, Ricciotti E, Dovizio M, Di Francesco A, Tacconelli S, Capone ML,
Patrignani P. Effects of AF3442
[N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of
human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human
monocytes in vitro. Biochem Pharmacol. 2010 Apr 1;79(7):974-81. doi:
10.1016/j.bcp.2009.11.011. Epub 2009 Nov 27. PubMed PMID: 19925781.