WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206499
Description: ABI-011 is a novel thiocolchicine dimer with antitubulin and topisomerase 1 inhibitor. ABI-011 significantly inhibited new microvessel formation and disrupted established microvessels even at the dose of 0.01 µg/ml. In the chicken embryonic CAM assay, ABI-011 demonstrated potent antiangiogenic activity in a concentration-dependent manner, with over 90% inhibition at 5 µg without affecting viability. ABI-011 exhibited potent and specific antiangiogenic and vascular disrupting activities both in vitro and in vivo. ABI-011 was determined to be a more potent vascular disrupting antitumor agent with better therapeutic index than CA4P.
MedKoo Cat#: 206499
Synonym: ABI-011; ABI 011; ABI011.
IUPAC/Chemical Name: Unknown
SMILES Code: Unknown