WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206498
CAS#: LXH254 HCl
Description: Naporafenib, also known as LXH254, is an orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, pan-RAF inhibitor LXH254 binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types..
MedKoo Cat#: 206498
Name: Naporafenib HCl
CAS#: LXH254 HCl
Chemical Formula: C25H26ClF3N4O4
Molecular Weight: 538.9522
Elemental Analysis: C, 55.71; H, 4.86; Cl, 6.58; F, 10.58; N, 10.40; O, 11.87
LXH254 HCl is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: LXH254; LXH-254; LXH 254; LXH254 HCl; LXH254 hydrochloride; Naporafenib HCl; Naporafenib hydrochloride
IUPAC/Chemical Name: N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide hydrochloride
InChi Key: SBMYWWMMWVWGKQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H25F3N4O4.ClH/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33;/h2-5,12-15,33H,6-11H2,1H3,(H,30,34);1H
SMILES Code: O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC(OCCO)=NC(N4CCOCC4)=C3)=C2.[H]Cl
The following data is based on the product molecular weight 538.9522 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|