Ripretinib free base
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MedKoo CAT#: 206497

CAS#: 1442472-39-0 (free base)

Description: Ripretinib, also known as DCC-2618, is a potent, orally active and selective KIT/PDGFR inhibitor with potential antineoplastic activity. DCC-2618 targets and binds to both wild-type and mutant forms of KIT and PDGFRa specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. In May 2020, FDA Approves Qinlock (ripretinib) for the Treatment of Fourth-Line Gastrointestinal Stromal Tumor


Chemical Structure

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Ripretinib free base
CAS# 1442472-39-0 (free base)

Theoretical Analysis

MedKoo Cat#: 206497
Name: Ripretinib free base
CAS#: 1442472-39-0 (free base)
Chemical Formula: C24H21BrFN5O2
Exact Mass: 509.0863
Molecular Weight: 510.3674
Elemental Analysis: C, 56.48; H, 4.15; Br, 15.66; F, 3.72; N, 13.72; O, 6.27

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 750 Same day
200mg USD 1250 Same day
500mg USD 2150 Same day
1g USD 3250 Same day
2g USD 5250 Same day
5g USD 7250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-01. Prices are subject to change without notice.

Ripretinib (DCC-2618) , purity > 98%, is in stock. The same day shipping out after order is received.

Related CAS #: 1442472-39-0 (free base)   Ripretinib HCl   1225278-16-9 (wrong structure for DCC-2618)    

Synonym: DCC-2618; DCC 2618; DCC2618; DP 2618; DP-2618; DP2618; Ripretinib;

IUPAC/Chemical Name: 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

InChi Key: CEFJVGZHQAGLHS-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33)

SMILES Code: O=C(NC1=CC(C2=CC3=C(C=C(NC)N=C3)N(CC)C2=O)=C(Br)C=C1F)NC4=CC=CC=C4

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO, not in water 100.0

Preparing Stock Solutions

The following data is based on the product molecular weight 510.3674 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Baird JH, Gotlib J. Clinical Validation of KIT Inhibition in Advanced Systemic
Mastocytosis. Curr Hematol Malig Rep. 2018 Oct;13(5):407-416. doi:
10.1007/s11899-018-0469-3. Review. PubMed PMID: 30155614.

2: Schneeweiss M, Peter B, Bibi S, Eisenwort G, Smiljkovic D, Blatt K, Jawhar M,
Berger D, Stefanzl G, Herndlhofer S, Greiner G, Hoermann G, Hadzijusufovic E,
Gleixner KV, Bettelheim P, Geissler K, Sperr WR, Reiter A, Arock M, Valent P. The
KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of
multiple neoplastic cell types in advanced mastocytosis. Haematologica. 2018
May;103(5):799-809. doi: 10.3324/haematol.2017.179895. Epub 2018 Feb 8. PubMed
PMID: 29439183; PubMed Central PMCID: PMC5927976.

3: BLU-285, DCC-2618 Show Activity against GIST. Cancer Discov. 2017
Feb;7(2):121-122. doi: 10.1158/2159-8290.CD-NB2016-165. Epub 2017 Jan 11. PubMed
PMID: 28077435.



Additional Information

Note: Many vendors listed wrong structure with CAS#1225278-16-9