EPI-506

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206494

CAS#: None

Description: EPI-506 is a potent and selective NTD inhibitor (inhibitor of the androgen receptor (AR) N-terminal domain (NTD)). In vitro and in vivo studies have shown activity against full length AR and constitutively active AR splice variants, including AR-V7 (associated with resistance to abiraterone and enzalutamide). EPI-506 is expected to be effective in mCRPC driven by both canonical and aberrant AR signaling by targeting the NTD common to full length and splice variant AR. EPI-506 is the first agent with the potential to inhibit both canonical and variant-mediated AR signaling.


Chemical Structure

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EPI-506
CAS# None

Theoretical Analysis

MedKoo Cat#: 206494
Name: EPI-506
CAS#: None
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: EPI-506; EPI 506; EPI506.

IUPAC/Chemical Name: Unknown

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Maughan BL, Antonarakis ES. Clinical Relevance of Androgen Receptor Splice
Variants in Castration-Resistant Prostate Cancer. Curr Treat Options Oncol. 2015
Dec;16(12):57. doi: 10.1007/s11864-015-0375-z. PubMed PMID: 26537882.