WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407233
CAS#: 496864-14-3
Description: Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM). Other measured targets: Cyclin-Dependent Kinase 1 (CDK1) (IC50 850.0 nM); Cyclin-Dependent Kinase 5 (CDK5) (IC50 13000.0 nM). Aloisine inhibits cell proliferation by arresting cells in both G1 and G2.
MedKoo Cat#: 407233
Name: Aloisine B
CAS#: 496864-14-3
Chemical Formula: C15H14ClN3
Exact Mass: 271.0876
Molecular Weight: 271.748
Elemental Analysis: C, 66.30; H, 5.19; Cl, 13.05; N, 15.46
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Aloisine B
IUPAC/Chemical Name: 6-(4-chlorophenyl)-7-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine
InChi Key: GFJIABMYYUGNEC-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)
SMILES Code: CC(C1=C(C2=CC=C(Cl)C=C2)NC3=NC=CN=C31)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 271.748 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M,
Endicott J, Vierfond JM, Meijer L. Aloisines, a new family of CDK/GSK-3
inhibitors. SAR study, crystal structure in complex with CDK2, enzyme
selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. PubMed
PMID: 12519061.
