Aloisine B

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407233

CAS#: 496864-14-3

Description: Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM). Other measured targets: Cyclin-Dependent Kinase 1 (CDK1) (IC50 850.0 nM); Cyclin-Dependent Kinase 5 (CDK5) (IC50 13000.0 nM). Aloisine inhibits cell proliferation by arresting cells in both G1 and G2.


Chemical Structure

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Aloisine B
CAS# 496864-14-3

Theoretical Analysis

MedKoo Cat#: 407233
Name: Aloisine B
CAS#: 496864-14-3
Chemical Formula: C15H14ClN3
Exact Mass: 271.0876
Molecular Weight: 271.748
Elemental Analysis: C, 66.30; H, 5.19; Cl, 13.05; N, 15.46

Size Price Shipping out time Quantity
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Pricing updated 2021-03-03. Prices are subject to change without notice.

Aloisine B, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: Aloisine B

IUPAC/Chemical Name: 6-(4-chlorophenyl)-7-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine

InChi Key: GFJIABMYYUGNEC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)

SMILES Code: CC(C1=C(C2=CC=C(Cl)C=C2)NC3=NC=CN=C31)C

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 271.748 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M,
Endicott J, Vierfond JM, Meijer L. Aloisines, a new family of CDK/GSK-3
inhibitors. SAR study, crystal structure in complex with CDK2, enzyme
selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. PubMed
PMID: 12519061.