WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407233
Description: Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM). Other measured targets: Cyclin-Dependent Kinase 1 (CDK1) (IC50 850.0 nM); Cyclin-Dependent Kinase 5 (CDK5) (IC50 13000.0 nM). Aloisine inhibits cell proliferation by arresting cells in both G1 and G2.
MedKoo Cat#: 407233
Name: Aloisine B
Chemical Formula: C15H14ClN3
Exact Mass: 271.0876
Molecular Weight: 271.748
Elemental Analysis: C, 66.30; H, 5.19; Cl, 13.05; N, 15.46
Aloisine B, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: Aloisine B
IUPAC/Chemical Name: 6-(4-chlorophenyl)-7-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine
InChi Key: GFJIABMYYUGNEC-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)
SMILES Code: CC(C1=C(C2=CC=C(Cl)C=C2)NC3=NC=CN=C31)C
The following data is based on the product molecular weight 271.748 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M,
Endicott J, Vierfond JM, Meijer L. Aloisines, a new family of CDK/GSK-3
inhibitors. SAR study, crystal structure in complex with CDK2, enzyme
selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. PubMed