Aloisine A
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MedKoo CAT#: 407232

CAS#: 496864-16-5

Description: Aloisine A is a potent and selective CDK/GSK-3 inhibitor. Aloisine A inhibits cell proliferation by arresting cells in both G1 and G2. IC50 data of Aloisine A: Cdc2 (CDK1)/cyclin B (IC50 = 150nM), Cdk2/cyclin A (IC50 = 120nM), Cdk2/cyclin E (IC50 = 400nM), Cdk5/p25 (IC50 = 200nM), Cdk5/p35 (IC50 = 160nM), and GSK-3α (IC50 = 500nM). Aloisine A also inhibits GSK-3β (IC50 = 650nM) and JNK (c-Jun N-terminal kinase) (IC50~3-10μM). Aloisine A blocks the cell cycle in both G1 and G2 phase.


Chemical Structure

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Aloisine A
CAS# 496864-16-5

Theoretical Analysis

MedKoo Cat#: 407232
Name: Aloisine A
CAS#: 496864-16-5
Chemical Formula: C16H17N3O
Exact Mass: 267.1372
Molecular Weight: 267.332
Elemental Analysis: C, 71.89; H, 6.41; N, 15.72; O, 5.98

Size Price Shipping out time Quantity
5mg USD 250 2 Weeks
10mg USD 370 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-24. Prices are subject to change without notice.

Aloisine A purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: Aloisine A

IUPAC/Chemical Name: 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol

InChi Key: PRIGRJPRGZCFAS-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)

SMILES Code: CCCCC1=C(C2=CC=C(C=C2)O)NC3=C1N=CC=N3

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 267.332 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic
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10.1016/j.antiviral.2010.03.007. Epub 2010 Mar 20. PubMed PMID: 20307580; PubMed
Central PMCID: PMC2866756.

3: Corbel C, Haddoub R, Guiffant D, Lozach O, Gueyrard D, Lemoine J, Ratin M,
Meijer L, Bach S, Goekjian P. Identification of potential cellular targets of
aloisine A by affinity chromatography. Bioorg Med Chem. 2009 Aug
1;17(15):5572-82. doi: 10.1016/j.bmc.2009.06.024. Epub 2009 Jun 18. PubMed PMID:
19596197.

4: Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M,
Endicott J, Vierfond JM, Meijer L. Aloisines, a new family of CDK/GSK-3
inhibitors. SAR study, crystal structure in complex with CDK2, enzyme
selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. PubMed
PMID: 12519061.