WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206493
Description: ACY-775 is a potent and selective HDAC6 inhbiitor. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 shares the antidepressant-like properties of other HDAC inhibitors, such as SAHA and MS-275, in the tail suspension test and social defeat paradigm.
MedKoo Cat#: 206493
Chemical Formula: C17H19FN4O2
Exact Mass: 330.1492
Molecular Weight: 330.36
Elemental Analysis: C, 61.81; H, 5.80; F, 5.75; N, 16.96; O, 9.69
ACY-775, purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: ACY-775; ACY 775; ACY775.
IUPAC/Chemical Name: 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide
InChi Key: IYBURCQQEUNLDL-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H19FN4O2/c18-14-6-4-5-13(9-14)17(7-2-1-3-8-17)21-16-19-10-12(11-20-16)15(23)22-24/h4-6,9-11,24H,1-3,7-8H2,(H,22,23)(H,19,20,21)
SMILES Code: O=C(C1=CN=C(NC2(C3=CC=CC(F)=C3)CCCCC2)N=C1)NO
The following data is based on the product molecular weight 330.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Jochems J, Boulden J, Lee BG, Blendy JA, Jarpe M, Mazitschek R, Van Duzer JH,
Jones S, Berton O. Antidepressant-like properties of novel HDAC6-selective
inhibitors with improved brain bioavailability. Neuropsychopharmacology. 2014
Jan;39(2):389-400. doi: 10.1038/npp.2013.207. Epub 2013 Aug 19. PubMed PMID:
23954848; PubMed Central PMCID: PMC3870780.
2: Mithraprabhu S, Khong T, Jones SS, Spencer A. Histone deacetylase (HDAC)
inhibitors as single agents induce multiple myeloma cell death principally
through the inhibition of class I HDAC. Br J Haematol. 2013 Aug;162(4):559-62.
doi: 10.1111/bjh.12388. Epub 2013 May 21. PubMed PMID: 23692150.