WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206493

CAS#: 1375466-18-4

Description: ACY-775 is a potent and selective HDAC6 inhbiitor. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 shares the antidepressant-like properties of other HDAC inhibitors, such as SAHA and MS-275, in the tail suspension test and social defeat paradigm.

Chemical Structure

CAS# 1375466-18-4

Theoretical Analysis

MedKoo Cat#: 206493
Name: ACY-775
CAS#: 1375466-18-4
Chemical Formula: C17H19FN4O2
Exact Mass: 330.1492
Molecular Weight: 330.36
Elemental Analysis: C, 61.81; H, 5.80; F, 5.75; N, 16.96; O, 9.69

Size Price Shipping out time Quantity
10mg USD 75 Same Day
25mg USD 150 Same Day
50mg USD 250 Same Day
100mg USD 450 Same Day
200mg USD 750 Same Day
500mg USD 1650 Same Day
1g USD 2650 2 Weeks
2g USD 4650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-27. Prices are subject to change without notice.

ACY-775, purity > 98%, is in stock. The same day shipping out after order is received.

Synonym: ACY-775; ACY 775; ACY775.

IUPAC/Chemical Name: 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide


InChi Code: InChI=1S/C17H19FN4O2/c18-14-6-4-5-13(9-14)17(7-2-1-3-8-17)21-16-19-10-12(11-20-16)15(23)22-24/h4-6,9-11,24H,1-3,7-8H2,(H,22,23)(H,19,20,21)


Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Preparing Stock Solutions

The following data is based on the product molecular weight 330.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jochems J, Boulden J, Lee BG, Blendy JA, Jarpe M, Mazitschek R, Van Duzer JH,
Jones S, Berton O. Antidepressant-like properties of novel HDAC6-selective
inhibitors with improved brain bioavailability. Neuropsychopharmacology. 2014
Jan;39(2):389-400. doi: 10.1038/npp.2013.207. Epub 2013 Aug 19. PubMed PMID:
23954848; PubMed Central PMCID: PMC3870780.

2: Mithraprabhu S, Khong T, Jones SS, Spencer A. Histone deacetylase (HDAC)
inhibitors as single agents induce multiple myeloma cell death principally
through the inhibition of class I HDAC. Br J Haematol. 2013 Aug;162(4):559-62.
doi: 10.1111/bjh.12388. Epub 2013 May 21. PubMed PMID: 23692150.