Chlorpromazine Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317517

CAS#: 69-09-0 (HCl)

Description: Chlorpromazine hydrochloride is the salt form of chlorpromazine, a phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine hydrochloride exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions. Other uses include the treatment of bipolar disorder, attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery.

Chemical Structure

Chlorpromazine Hydrochloride
CAS# 69-09-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 317517
Name: Chlorpromazine Hydrochloride
CAS#: 69-09-0 (HCl)
Chemical Formula: C17H20Cl2N2S
Exact Mass:
Molecular Weight: 355.33
Elemental Analysis: C, 57.46; H, 5.67; Cl, 19.96; N, 7.88; S, 9.02

Price and Availability

Size Price Availability Quantity
1.0g USD 90.0 2 Weeks
2.0g USD 150.0 2 Weeks
5.0g USD 250.0 2 Weeks
10.0g USD 350.0 2 Weeks
20.0g USD 450.0 2 Weeks
50.0g USD 750.0 2 Weeks
100.0g USD 950.0 2 Weeks
Bulk inquiry

Related CAS #: 69-09-0 (HCl)   50-53-3 (free)  

Synonym: Chloropromazine Hydrochloride; Sonazine; Promacid; Chloractil; Klorpromex; Fenactil; Hydrochloride, Chlorpromazine; Largactil; Propaphenin; Thorazine;

IUPAC/Chemical Name: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride


InChi Code: InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H


Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 355.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Halayqa M, Domańska U. PLGA biodegradable nanoparticles containing
perphenazine or chlorpromazine hydrochloride: effect of formulation and release.
Int J Mol Sci. 2014 Dec 22;15(12):23909-23. doi: 10.3390/ijms151223909. PubMed
PMID: 25535080; PubMed Central PMCID: PMC4284797.

2: Nagaraja P, Aradhana N, Suma A, Shivakumar A, Chamaraja NA. Quantification of
antioxidants by using chlorpromazine hydrochloride: application of the method to
food and medicinal plant samples. Anal Sci. 2014;30(2):251-6. PubMed PMID:

3: Liu JM, Lin LP, Wang XX, Lin X, Zhou P, Lin SQ, Zheng ZY. Highly sensitive
detection of residual chlorpromazine hydrochloride with solid substrate room
temperature phosphorimetry. J Fluoresc. 2012 Jul;22(4):1087-94. doi:
10.1007/s10895-012-1047-z. Epub 2012 Apr 24. PubMed PMID: 22527301.

4: Rai V, Dayan N, Michniak-Kohn B. A comparative evaluation of photo-toxic
effect of fractionated melanin and chlorpromazine hydrochloride on human (dermal
fibroblasts and epidermal keratinocytes) and mouse cell line/s (fibroblast Balb/c
3T3). Toxicol In Vitro. 2011 Mar;25(2):538-44. doi: 10.1016/j.tiv.2010.11.017.
Epub 2010 Dec 4. PubMed PMID: 21134440.

5: Chen P, Hu X, Liu S, Liu Z, Song Y. Study on the resonance nonlinear
scattering spectra of the interactions of promethazine hydrochloride and
chlorpromazine hydrochloride with 12-tungstophosphoric acid and their analytical
applications. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Sep 15;77(1):207-12.
doi: 10.1016/j.saa.2010.05.009. Epub 2010 May 24. PubMed PMID: 20541454.

6: Izumi Y, Watanabe T, Awasaki N, Hikawa K, Minagi T, Chatani F. Collaborative
work on evaluation of ovarian toxicity. 16) Effects of 2 or 4 weeks repeated dose
studies and fertility study of Chlorpromazine hydrochloride in rats. J Toxicol
Sci. 2009;34 Suppl 1:SP167-74. PubMed PMID: 19265283.

7: Nussio MR, Sykes MJ, Miners JO, Shapter JG. Kinetics membrane disruption due
to drug interactions of chlorpromazine hydrochloride. Langmuir. 2009 Jan
20;25(2):1086-90. doi: 10.1021/la803288s. PubMed PMID: 19093750.

8: Alam MS, Naqvi AZ, Kabir-ud-Din. Influence of additives on the clouding
phenomenon of chlorpromazine hydrochloride solutions. Colloids Surf B
Biointerfaces. 2008 May 1;63(1):122-8. doi: 10.1016/j.colsurfb.2007.11.012. Epub
2007 Nov 28. PubMed PMID: 18178389.

9: Ni YN, Qi ZB. [Differential kinetic spectrophotometric determination of
chlorpromazine hydrochloride and promethazine hydrochloride by chemometric
method]. Guang Pu Xue Yu Guang Pu Fen Xi. 2006 Jul;26(7):1364-7. Chinese. PubMed
PMID: 17020062.

10: Niu W, Feng N, Nie F, Lu J. Investigating the post-chemiluminescence behavior
of phenothiazine medications in the luminol-potassium ferricyanide system:
molecular imprinting-post-chemiluminescence method for the determination of
chlorpromazine hydrochloride. Anal Bioanal Chem. 2006 May;385(1):153-60. Epub
2006 Mar 18. PubMed PMID: 16547741.

11: Daniel D, Gutz IG. Spectroelectrochemical determination of chlorpromazine
hydrochloride by flow-injection analysis. J Pharm Biomed Anal. 2005 Feb
23;37(2):281-6. PubMed PMID: 15708668.

12: Kollmorgen D, Kraut B. Determination of methylparaben, propylparaben and
chlorpromazine in chlorpromazine hydrochloride oral solution by high-performance
liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998 Apr
10;707(1-2):181-7. PubMed PMID: 9613948.

13: Zhou Z, Wang L, Peng Y, Zhang X. [Determination of content of chlorpromazine
hydrochloride in compound metamizole sodium microenema by acid-dye colorimetric
method]. Hua Xi Yi Ke Da Xue Xue Bao. 1996 Dec;27(4):428-31. Chinese. PubMed
PMID: 9389020.

14: Liu YM, Yu RQ. [Kalman filtering--UV spectrophotometric simultaneous
determination of chlorpromazine hydrochloride and promethazine hydrochloride].
Yao Xue Xue Bao. 1987 Dec;22(12):913-7. Chinese. PubMed PMID: 3450135.

15: Paiement J. Cmc of mixtures of chlorpromazine hydrochloride and polysorbate
80 determined by pH measurements. J Pharm Pharmacol. 1984 Sep;36(9):614-5. PubMed
PMID: 6149286.

16: Binford JS Jr, Wadsö I. Calorimetric determination of the partition
coefficient for chlorpromazine hydrochloride in aqueous suspensions of
dimyristoylphosphatidylcholine vesicles. J Biochem Biophys Methods. 1984
May;9(2):121-31. PubMed PMID: 6736558.

17: Voigt R, Thomas G. [Effect of adjuvants on the pharmaceutical and biological
availability of chlorpromazine hydrochloride]. Pharmazie. 1983 Nov;38(11):736-9.
German. PubMed PMID: 6669593.

18: Keeffe EB, Blankenship NM, Scharschmidt BF. Alteration of rat liver plasma
membrane fluidity and ATPase activity by chlorpromazine hydrochloride and its
metabolites. Gastroenterology. 1980 Aug;79(2):222-31. PubMed PMID: 6249693.

19: Takahashi DM. Rapid determination of chlorpromazine hydrochloride and two
oxidation products in various pharmaceutical samples using high-performance
liquid chromatography and fluorescence detection. J Pharm Sci. 1980
Feb;69(2):184-7. PubMed PMID: 7359320.

20: Ros E, Small DM, Carey MC. Effects of chlorpromazine hydrochloride on bile
salt synthesis, bile formation and biliary lipid secretion in the rhesus monkey:
a model for chlorpromazine-induced cholestasis. Eur J Clin Invest. 1979
Feb;9(1):29-41. PubMed PMID: 110598.