Chlorpromazine Hydrochloride
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MedKoo CAT#: 317517

CAS#: 69-09-0 (HCl)

Description: Chlorpromazine hydrochloride is the salt form of chlorpromazine, a phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine hydrochloride exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions. Other uses include the treatment of bipolar disorder, attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery.


Chemical Structure

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Chlorpromazine Hydrochloride
CAS# 69-09-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 317517
Name: Chlorpromazine Hydrochloride
CAS#: 69-09-0 (HCl)
Chemical Formula: C17H20Cl2N2S
Exact Mass:
Molecular Weight: 355.33
Elemental Analysis: C, 57.46; H, 5.67; Cl, 19.96; N, 7.88; S, 9.02

Price and Availability

Size Price Availability Quantity
1.0g USD 90.0 2 Weeks
2.0g USD 150.0 2 Weeks
5.0g USD 250.0 2 Weeks
10.0g USD 350.0 2 Weeks
20.0g USD 450.0 2 Weeks
50.0g USD 750.0 2 Weeks
100.0g USD 950.0 2 Weeks
Bulk inquiry

Related CAS #: 69-09-0 (HCl)   50-53-3 (free)  

Synonym: Chloropromazine Hydrochloride; Sonazine; Promacid; Chloractil; Klorpromex; Fenactil; Hydrochloride, Chlorpromazine; Largactil; Propaphenin; Thorazine;

IUPAC/Chemical Name: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride

InChi Key: FBSMERQALIEGJT-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

SMILES Code: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl

Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 355.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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perphenazine or chlorpromazine hydrochloride: effect of formulation and release.
Int J Mol Sci. 2014 Dec 22;15(12):23909-23. doi: 10.3390/ijms151223909. PubMed
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scattering spectra of the interactions of promethazine hydrochloride and
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of phenothiazine medications in the luminol-potassium ferricyanide system:
molecular imprinting-post-chemiluminescence method for the determination of
chlorpromazine hydrochloride. Anal Bioanal Chem. 2006 May;385(1):153-60. Epub
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11: Daniel D, Gutz IG. Spectroelectrochemical determination of chlorpromazine
hydrochloride by flow-injection analysis. J Pharm Biomed Anal. 2005 Feb
23;37(2):281-6. PubMed PMID: 15708668.

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chlorpromazine in chlorpromazine hydrochloride oral solution by high-performance
liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998 Apr
10;707(1-2):181-7. PubMed PMID: 9613948.

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PMID: 9389020.

14: Liu YM, Yu RQ. [Kalman filtering--UV spectrophotometric simultaneous
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15: Paiement J. Cmc of mixtures of chlorpromazine hydrochloride and polysorbate
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PMID: 6149286.

16: Binford JS Jr, Wadsö I. Calorimetric determination of the partition
coefficient for chlorpromazine hydrochloride in aqueous suspensions of
dimyristoylphosphatidylcholine vesicles. J Biochem Biophys Methods. 1984
May;9(2):121-31. PubMed PMID: 6736558.

17: Voigt R, Thomas G. [Effect of adjuvants on the pharmaceutical and biological
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German. PubMed PMID: 6669593.

18: Keeffe EB, Blankenship NM, Scharschmidt BF. Alteration of rat liver plasma
membrane fluidity and ATPase activity by chlorpromazine hydrochloride and its
metabolites. Gastroenterology. 1980 Aug;79(2):222-31. PubMed PMID: 6249693.

19: Takahashi DM. Rapid determination of chlorpromazine hydrochloride and two
oxidation products in various pharmaceutical samples using high-performance
liquid chromatography and fluorescence detection. J Pharm Sci. 1980
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20: Ros E, Small DM, Carey MC. Effects of chlorpromazine hydrochloride on bile
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Feb;9(1):29-41. PubMed PMID: 110598.