WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317516
CAS#: 113-92-8
Description: Chlorpheniramine maleate is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than Promethazine. Although not generally approved as an antidepressant or anti-anxiety medication, chlorphenamine appears to have these properties as well. In addition to being an histamine H1 receptor antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI.
MedKoo Cat#: 317516
Name: Chlorpheniramine Maleate
CAS#: 113-92-8
Chemical Formula: C20H23ClN2O4
Exact Mass:
Molecular Weight: 390.86
Elemental Analysis: C, 61.46; H, 5.93; Cl, 9.07; N, 7.17; O, 16.37
Related CAS #: 113-92-8 (maleate) 132-22-9 (free)
Synonym: Chlorpheniramine Maleate; Piriton; Chlortrimeton; Deconamine; Neorestamin; Bayer Brand of Chlorpheniramine Maleate; Chlo-Amine; Chlor-100; Chlor-Trimeton;
IUPAC/Chemical Name: 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate
InChi Key: DBAKFASWICGISY-BTJKTKAUSA-N
InChi Code: InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code: CN(CCC(C1=CC=CC=N1)C2=CC=C(Cl)C=C2)C.O=C(O)/C=C\C(O)=O
Appearance: White crystalline solid.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 390.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Demirel F, Gulec M, Kartal O, Yesıllik S, Baysan A, Musabak U, Sener O.
Allergic reaction to chlorpheniramine maleate. Ann Allergy Asthma Immunol. 2015
Aug;115(2):150-2. doi: 10.1016/j.anai.2015.05.009. PubMed PMID: 26250772.
2: Ranganathan AT, Chandran CR, Prabhakar P, Lakshmiganthan M, Parthasaradhi T.
Plasma cell gingivitis: treatment with chlorpheniramine maleate. Int J
Periodontics Restorative Dent. 2015 May-Jun;35(3):411-3. doi: 10.11607/prd.2111.
PubMed PMID: 25909529.
3: Zhang F. Physicochemical properties and mechanisms of drug release from
melt-extruded granules consisting of chlorpheniramine maleate and Eudragit FS.
Drug Dev Ind Pharm. 2015 Jun 24:1-9. [Epub ahead of print] PubMed PMID: 26065535.
4: Zhou LW, Wu ZS, Shi XY, Xu MF, Zhang Q, Qiao YJ. [Research on NIR-CI
parameters optimization of chlorpheniramine maleate tablets based on binary image
and statistical measurement]. Guang Pu Xue Yu Guang Pu Fen Xi. 2014
Oct;34(10):2821-6. Chinese. PubMed PMID: 25739232.
5: Lou H, Liu M, Qu W, Hu Z, Brunson E, Johnson J, Almoazen H. Evaluation of
Chlorpheniramine Maleate microparticles in orally disintegrating film and orally
disintegrating tablet for pediatrics. Drug Dev Ind Pharm. 2014 Jul;40(7):910-8.
doi: 10.3109/03639045.2013.789907. Epub 2013 Apr 26. PubMed PMID: 23621768.
6: Jelvehgari M, Barghi L, Barghi F. Preparation of Chlorpheniramine
Maleate-loaded Alginate/Chitosan Particulate Systems by the Ionic Gelation Method
for Taste Masking. Jundishapur J Nat Pharm Prod. 2014 Feb;9(1):39-48. Epub 2014
Feb 20. PubMed PMID: 24644438; PubMed Central PMCID: PMC3957142.
7: Peng C, Lv M, Tian J, Huang Y, Tian Y, Zhang Z. Herb-drug pharmacokinetic
interaction of artificial calculus bovis with diclofenac sodium and
chlorpheniramine maleate in rats. J Pharm Pharmacol. 2013 Jul;65(7):1064-72. doi:
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8: Ali NW, Hegazy MA, Abdelkawy M, Abdelfatah RM. Report: Simultaneous
determination of naphazoline hydrochloride, chlorpheniramine maleate and
methylene blue in their ternary mixture. Pak J Pharm Sci. 2013 May;26(3):641-8.
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9: Yewale CP, Rathi MN, Kore GG, Jadhav GV, Wagh MP. Formulation and development
of taste masked fast-disintegrating tablets (FDTs) of Chlorpheniramine maleate
using ion-exchange resins. Pharm Dev Technol. 2013 Mar-Apr;18(2):367-76. doi:
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10: Kumar A, Sharma R, Nair A, Saini G. Development and validation of RP-HPLC
method for simultaneous estimation of nimesulide, phenylephrine hydrochloride,
chlorpheniramine maleate and caffeine anhydrous in pharmaceutical dosage form.
Acta Pol Pharm. 2012 Nov-Dec;69(6):1017-22. PubMed PMID: 23285660.
11: Krishnaprasad K, Manshani P, Karankumar J. Health outcome and safety
assessment of a fixed dose combination of Amantadine, Paracetamol,
Chlorpheniramine maleate, and Phenylephrine introduction in India: A prescription
event monitoring study. Perspect Clin Res. 2012 Apr;3(2):62-5. doi:
10.4103/2229-3485.96447. PubMed PMID: 22701822; PubMed Central PMCID: PMC3371550.
12: Misumi N, Hiraike M, Nawata F, Hashimoto M, Tanigawa K, Takase I, Nabeshima
A, Honda S. [Protective effects of d-chlorpheniramine maleate pre-treatment
against acute side effects of Irinotecan(CPT- 11)]. Gan To Kagaku Ryoho. 2011
Jul;38(7):1149-53. Japanese. PubMed PMID: 21772100.
13: Kim MH, Lee SM, Lee SH, Kwon HS, Kim SH, Cho SH, Min KU, Kim YY, Chang YS. A
case of chlorpheniramine maleate-induced hypersensitivity with aspirin
intolerance. Allergy Asthma Immunol Res. 2011 Jan;3(1):62-4. doi:
10.4168/aair.2011.3.1.62. Epub 2010 Jul 29. PubMed PMID: 21217928; PubMed Central
PMCID: PMC3005322.
14: Al Lawati HA, Suliman FE, Al Kindy SM, Al-Lawati AM, Varma GB, Nour IE.
Enhancement of on chip chemiluminescence signal intensity of
tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate system for analysis of
chlorpheniramine maleate in pharmaceutical formulations. Talanta. 2010 Oct
15;82(5):1999-2002. doi: 10.1016/j.talanta.2010.08.018. Epub 2010 Aug 24. PubMed
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chlorpheniramine maleate nasal gel. Pharm Dev Technol. 2010 Sep-Oct;15(5):484-91.
doi: 10.3109/10837450903286545. PubMed PMID: 20735301.
16: Yin SF, Qiu ZY. [Simultaneous determination of ibuprofen and pseudoephedrin
hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin
tablets by HPLC]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jul;30(7):1703-4. Chinese.
PubMed PMID: 20650805.
17: Valderrama P, Romero AL, Imamura PM, Magalhães IR, Bonato PS, Poppi RJ.
Quantification of chlorpheniramine maleate enantiomers by ultraviolet
spectroscopy and chemometric methods. Anal Bioanal Chem. 2010 May;397(1):181-8.
doi: 10.1007/s00216-010-3472-7. Epub 2010 Feb 11. PubMed PMID: 20148242.
18: Al-Rimawi F. Normal-phase LC method for simultaneous analysis of
pseudophedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramine
maleate, and paracetamol in tablet formulations. Saudi Pharm J. 2010
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19: Samadi-Maybodi A, Hassani Nejad-Darzi SK. Simultaneous determination of
paracetamol, phenylephrine hydrochloride and chlorpheniramine maleate in
pharmaceutical preparations using multivariate calibration 1. Spectrochim Acta A
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electrophoresis method for the simultaneous determination of dextromethorphan
hydrobromur, phenylephrine hydrochloride, paracetamol and chlorpheniramine
maleate in a pharmaceutical preparation using response surface methodology. Anal
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